Document Detail

Possible monoamine oxidase inhibitor-serotonin uptake inhibitor interaction: fluoxetine clinical data and preclinical findings.
MedLine Citation:
PMID:  8227489     Owner:  NLM     Status:  MEDLINE    
The primary objective of this article is to review information pertinent to and emphasize the seriousness of a potential adverse monoamine oxidase inhibitor (MAOI)-serotonin uptake inhibitor interaction by considering, within the context of preclinical data, clinical cases in which an MAOI and fluoxetine hydrochloride, a specific serotonin uptake inhibitor, were administered in close temporal proximity. Clinical cases were identified by a review of spontaneous adverse event reports submitted voluntarily to Eli Lilly and Company through its drug surveillance program and by a review of reports of MAOI interactions published in the scientific literature. A discussion of eight selected clinical cases of acute adverse reactions (seven with fatal outcomes; one with a favorable response after cyproheptadine therapy) reported to Eli Lilly and Company in which an MAOI was initiated concurrently or shortly after the discontinuation of fluoxetine and a review of preclinical data suggest a possible role of serotonin and/or serotonin-dopamine interactions in the hypermetabolic state that may occur when a serotonin uptake inhibitor and an MAOI are coadministered, although alternative etiologic processes are possible as well. Data reviewed reinforce the idea that the administration of an MAOI in close temporal proximity to fluoxetine is contraindicated.
C M Beasley; D N Masica; J H Heiligenstein; D E Wheadon; R L Zerbe
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  13     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-17     Completed Date:  1993-12-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-20     Citation Subset:  IM    
Psychopharmacology Division, Lilly Corporate Center, Indianapolis, Indiana 46285.
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MeSH Terms
Brain / drug effects,  physiopathology
Depressive Disorder / drug therapy*,  psychology
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Interactions
Drug Therapy, Combination
Fatal Outcome
Fluoxetine / administration & dosage,  adverse effects*,  pharmacokinetics
Middle Aged
Monoamine Oxidase Inhibitors / administration & dosage,  adverse effects*,  pharmacokinetics
Neurologic Examination / drug effects
Phenelzine / administration & dosage,  adverse effects,  pharmacokinetics
Product Surveillance, Postmarketing
Receptors, Serotonin / drug effects,  physiology
Tranylcypromine / administration & dosage,  adverse effects,  pharmacokinetics
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 0/Receptors, Serotonin; 155-09-9/Tranylcypromine; 51-71-8/Phenelzine; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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