| Possible monoamine oxidase inhibitor-serotonin uptake inhibitor interaction: fluoxetine clinical data and preclinical findings. | |
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MedLine Citation:
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PMID: 8227489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The primary objective of this article is to review information pertinent to and emphasize the seriousness of a potential adverse monoamine oxidase inhibitor (MAOI)-serotonin uptake inhibitor interaction by considering, within the context of preclinical data, clinical cases in which an MAOI and fluoxetine hydrochloride, a specific serotonin uptake inhibitor, were administered in close temporal proximity. Clinical cases were identified by a review of spontaneous adverse event reports submitted voluntarily to Eli Lilly and Company through its drug surveillance program and by a review of reports of MAOI interactions published in the scientific literature. A discussion of eight selected clinical cases of acute adverse reactions (seven with fatal outcomes; one with a favorable response after cyproheptadine therapy) reported to Eli Lilly and Company in which an MAOI was initiated concurrently or shortly after the discontinuation of fluoxetine and a review of preclinical data suggest a possible role of serotonin and/or serotonin-dopamine interactions in the hypermetabolic state that may occur when a serotonin uptake inhibitor and an MAOI are coadministered, although alternative etiologic processes are possible as well. Data reviewed reinforce the idea that the administration of an MAOI in close temporal proximity to fluoxetine is contraindicated. |
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Authors:
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C M Beasley; D N Masica; J H Heiligenstein; D E Wheadon; R L Zerbe |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 13 ISSN: 0271-0749 ISO Abbreviation: J Clin Psychopharmacol Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-12-17 Completed Date: 1993-12-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 312-20 Citation Subset: IM |
Affiliation:
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Psychopharmacology Division, Lilly Corporate Center, Indianapolis, Indiana 46285. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / drug effects, physiopathology Depressive Disorder / drug therapy*, psychology Dose-Response Relationship, Drug Drug Administration Schedule Drug Interactions Drug Therapy, Combination Fatal Outcome Female Fluoxetine / administration & dosage, adverse effects*, pharmacokinetics Humans Male Middle Aged Monoamine Oxidase Inhibitors / administration & dosage, adverse effects*, pharmacokinetics Neurologic Examination / drug effects Phenelzine / administration & dosage, adverse effects, pharmacokinetics Product Surveillance, Postmarketing Receptors, Serotonin / drug effects, physiology Tranylcypromine / administration & dosage, adverse effects, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Monoamine Oxidase Inhibitors; 0/Receptors, Serotonin; 155-09-9/Tranylcypromine; 51-71-8/Phenelzine; 54910-89-3/Fluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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