Document Detail


Possible mechanisms of left ventricular torsion evaluated by cardioreparative effects of telmisartan in patients with hypertension.
MedLine Citation:
PMID:  20382977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Left ventricular (LV) torsion may be an important component of normal LV systolic function. However, its mechanics remain unresolved. Two-dimensional (2-D) strain imaging is increasingly used to quantify LV torsion in the clinical setting. Telmisartan has cardioreparative effects, including attenuation of subendocardial myocardial fibrosis and improvement of LV remodelling. To clarify the mechanisms of LV torsion, in the present study, we evaluated changes in LV longitudinal deformation and torsion after medication with telmisartan using 2-D strain imaging in patients with hypertension (HT).
METHODS AND RESULTS: Telmisartan (20-40 mg daily) was administered to 37 previously untreated patients with HT. Two-dimensional strain echocardiography was performed after medication had been continued for 1-2 months with normal values for blood pressure (BP) (phase I) and for 12 months (phase II). In the phase II, relative LV wall thickness, LV mass index, LV torsion, and torsional rate were reduced, whereas the mean peak systolic longitudinal strain and strain rate were increased, compared to the phase I. LV torsion correlated well with relative LV wall thickness, but not LV mass index.
CONCLUSION: Our results obtained from cardioreparative effects of telmisartan suggested that LV torsion is associated with systolic longitudinal deformation related to subendocardial myocardial fibrosis, and/or LV concentric hypertrophy-related difference in torques between the subendocardial and subepicardial sides.
Authors:
Yukio Mizuguchi; Yoshifumi Oishi; Hirokazu Miyoshi; Arata Iuchi; Norio Nagase; Nusrat Ara; Takashi Oki
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Publication Detail:
Type:  Journal Article     Date:  2010-04-10
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  11     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2011-06-02     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  690-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II Type 1 Receptor Blockers / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Benzimidazoles / therapeutic use*
Benzoates / therapeutic use*
Echocardiography
Feasibility Studies
Female
Fibrosis / drug therapy
Heart Ventricles / drug effects,  pathology*,  ultrasonography
Humans
Hypertension / drug therapy*
Hypertrophy, Left Ventricular / etiology*,  pathology,  ultrasonography
Male
Middle Aged
Statistics as Topic
Stroke Volume
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Benzoates; U5SYW473RQ/telmisartan

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