Document Detail


Possible mechanism of the selectivity of the cytostatic action of antineoplastic preparations.
MedLine Citation:
PMID:  550904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model of the phenomenon of selectivity of antineoplastic phase-specific preparations in leukemia, based on the assumption that any proliferating cells are equally sensitive to the action of such preparations, is suggested. Therefore, selectivity, the concept and fundamental significance of which were formulated and substantiated by the authors earlier, can be expressed in terms of the proliferative pathways of the normal and leukemic populations, the ratio between which thus plays the deciding role in the selection of the optimum system of therapy. The concept of maximum selectivity, which is a convenient numerical characteristic of a preparation, was introduced. A comparative quantitative analysis was made of a number of antineoplastic preparations (vinblastine, vincristine, amethopterin, arabinosylcytosine, azaserine); it showed that the conclusions of the model do not contradict the experimental data.
Authors:
A A Konradov; E I Levitin; V M Maksimov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology bulletin of the Academy of Sciences of the USSR     Volume:  6     ISSN:  0098-2164     ISO Abbreviation:  Biol Bull Acad Sci USSR     Publication Date:    1979 May-Jun
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7513560     Medline TA:  Biol Bull Acad Sci USSR     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / metabolism*
Azaserine / therapeutic use
Cell Division / drug effects
Cytarabine / therapeutic use
Leukemia / drug therapy
Methotrexate / therapeutic use
Models, Biological
Thymidine / metabolism
Vinblastine / therapeutic use
Vincristine / therapeutic use
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 115-02-6/Azaserine; 147-94-4/Cytarabine; 50-89-5/Thymidine; 57-22-7/Vincristine; 59-05-2/Methotrexate; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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