Document Detail

Possible mechanism of the selectivity of the cytostatic action of antineoplastic preparations.
MedLine Citation:
PMID:  550904     Owner:  NLM     Status:  MEDLINE    
A model of the phenomenon of selectivity of antineoplastic phase-specific preparations in leukemia, based on the assumption that any proliferating cells are equally sensitive to the action of such preparations, is suggested. Therefore, selectivity, the concept and fundamental significance of which were formulated and substantiated by the authors earlier, can be expressed in terms of the proliferative pathways of the normal and leukemic populations, the ratio between which thus plays the deciding role in the selection of the optimum system of therapy. The concept of maximum selectivity, which is a convenient numerical characteristic of a preparation, was introduced. A comparative quantitative analysis was made of a number of antineoplastic preparations (vinblastine, vincristine, amethopterin, arabinosylcytosine, azaserine); it showed that the conclusions of the model do not contradict the experimental data.
A A Konradov; E I Levitin; V M Maksimov
Related Documents :
19922694 - Accuracy of genomic selection using stochastic search variable selection in australian ...
22133974 - Assessment of the development and implementation of tools in contract cleaning.
19493104 - A pixel selection rule based on the number of different-phase neighbours for the simula...
17947444 - Sequence-level population simulations over large genomic regions.
24829284 - A unifying framework for quantifying the nature of animal interactions.
24310484 - An interval estimation of expected response to selection.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology bulletin of the Academy of Sciences of the USSR     Volume:  6     ISSN:  0098-2164     ISO Abbreviation:  Biol Bull Acad Sci USSR     Publication Date:    1979 May-Jun
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7513560     Medline TA:  Biol Bull Acad Sci USSR     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / metabolism*
Azaserine / therapeutic use
Cell Division / drug effects
Cytarabine / therapeutic use
Leukemia / drug therapy
Methotrexate / therapeutic use
Models, Biological
Thymidine / metabolism
Vinblastine / therapeutic use
Vincristine / therapeutic use
Reg. No./Substance:
0/Antineoplastic Agents; 115-02-6/Azaserine; 147-94-4/Cytarabine; 50-89-5/Thymidine; 57-22-7/Vincristine; 59-05-2/Methotrexate; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Absorptive function of peripheral blood neutrophils in irradiated animals.
Next Document:  Influence of ultralow temperatures on the translating activity of cell-free extracts of different or...