Document Detail


Possible mechanism behind the adjuvant action of phosphate derivatives on rectal absorption of cefoxitin in rats and dogs.
MedLine Citation:
PMID:  6520749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism underlying the ability of phosphate derivatives to act as adjuvants and coadjuvants was examined in in vivo and in situ preparations in rats and dogs. The adjuvant effect of DL-alpha-glycerophosphate on the rectal absorption of sodium cefoxitin was greatly augmented by the presence of either sodium phytate or sodium tripolyphosphate. These coadjuvants only slightly enhanced cefoxitin rectal absorption when administered alone. Therefore, enhancement of the permeation of tripolyphosphate and phytate by alpha-glycerophosphate may be necessary before the coadjuvants can significantly affect cefoxitin absorption. The inhibitory effect of disodium 4,4'-diisothiocyano-2,2'-disulfonate stilbene, which is known to interact with the amino group in the protein fraction, on enhanced cefoxitin absorption suggests the involvement of the protein fraction in transport of cefoxitin across the rectal membrane.
Authors:
T Nishihata; C S Lee; B T Nghiem; T Higuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  73     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-02-27     Completed Date:  1985-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1523-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Pharmaceutic*
Animals
Biological Availability
Cefoxitin / metabolism*
Cell Membrane / metabolism
Dogs
Glycerophosphates / pharmacology
Intestinal Absorption / drug effects*
Male
Phosphates / pharmacology*
Phytic Acid / pharmacology
Polyphosphates / pharmacology
Rats
Rats, Inbred Strains
Rectum / metabolism*
Species Specificity
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Adjuvants, Pharmaceutic; 0/Glycerophosphates; 0/Phosphates; 0/Polyphosphates; 10380-08-2/triphosphoric acid; 35607-66-0/Cefoxitin; 57-03-4/alpha-glycerophosphoric acid; 83-86-3/Phytic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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