Document Detail

Possible mechanism for the antiarrhythmic effect of helium in anesthetized dogs.
MedLine Citation:
PMID:  5033644     Owner:  NLM     Status:  MEDLINE    
Breathing a mixture of 75 percent helium and 25 percent oxygen instead of 75 percent nitrogen and 25 percent oxygen reduced the occurrence of dangerous cardiac arrhythmias after ligation of the circumflex coronary artery in open-chest dogs anesthetized with pentobarbital. In dogs not subjected to circumflex ligation, the sensitivity of blood pressure, heart rate, and extrasystoles to epinephrine injected intravenously was not altered by the substitution of helium for nitrogen; however, helium did reduce the baseline heart rate and the concentration of endogenous plasma catecholamines. The antiarrhythmic effect of helium may thus be mediated by changes in sympathetic activity.
L Raymond; R B Weiskopf; M J Halsey; A Goldfien; E I Eger; J W Severinghaus
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  176     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1972 Jun 
Date Detail:
Created Date:  1972-08-10     Completed Date:  1972-08-10     Revised Date:  2011-12-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1250-2     Citation Subset:  IM    
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MeSH Terms
Anesthesia, General*
Anti-Arrhythmia Agents*
Arrhythmias, Cardiac / prevention & control
Blood Pressure / drug effects
Coronary Vessels / surgery
Epinephrine / blood,  pharmacology
Heart / drug effects*
Heart Rate / drug effects
Helium / pharmacology*
Nitrogen / pharmacology
Norepinephrine / blood
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 151-67-7/Halothane; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-59-7/Helium; 76-74-4/Pentobarbital; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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