| Possible mechanism for the antiarrhythmic effect of helium in anesthetized dogs. | |
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MedLine Citation:
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PMID: 5033644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Breathing a mixture of 75 percent helium and 25 percent oxygen instead of 75 percent nitrogen and 25 percent oxygen reduced the occurrence of dangerous cardiac arrhythmias after ligation of the circumflex coronary artery in open-chest dogs anesthetized with pentobarbital. In dogs not subjected to circumflex ligation, the sensitivity of blood pressure, heart rate, and extrasystoles to epinephrine injected intravenously was not altered by the substitution of helium for nitrogen; however, helium did reduce the baseline heart rate and the concentration of endogenous plasma catecholamines. The antiarrhythmic effect of helium may thus be mediated by changes in sympathetic activity. |
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Authors:
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L Raymond; R B Weiskopf; M J Halsey; A Goldfien; E I Eger; J W Severinghaus |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 176 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1972 Jun |
Date Detail:
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Created Date: 1972-08-10 Completed Date: 1972-08-10 Revised Date: 2011-12-27 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1250-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General* Animals Anti-Arrhythmia Agents* Arrhythmias, Cardiac / prevention & control Blood Pressure / drug effects Coronary Vessels / surgery Dogs Epinephrine / blood, pharmacology Halothane Heart / drug effects* Heart Rate / drug effects Helium / pharmacology* Ligation Nitrogen / pharmacology Norepinephrine / blood Pentobarbital |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 151-67-7/Halothane; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-59-7/Helium; 76-74-4/Pentobarbital; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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