| Possible involvement of the tip of temporal lobe in Landau-Kleffner syndrome. | |
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MedLine Citation:
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PMID: 17383838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Landau-Kleffner syndrome (LKS) is a childhood disorder of unknown etiology characterized by an acquired aphasia and epilepsy. We have performed comprehensive neurofunctional studies on an 8-year-old girl with typical LKS, with the aim of identifying lesions that may be responsible for her condition. 18F-fluoro-D-glucose (FDG) positron emission computed tomography (PET), 11C-Flumazenil (FMZ) PET, 99mTc-hexamethylpropyleneamine oxime single photon emission computed tomography (SPECT) and magnetoencephalography were performed before and after changes to the patient's medication led to a clinical improvement. Interictal SPECT showed hypoperfusion in the left frontal, left temporal, and left occipital lobes. 18F-FDG PET demonstrated a decrease in glucose metabolism medially in both temporal lobes and superiorly in the left temporal lobe. 11C-FMZ PET revealed a deficit in benzodiazepine receptor binding at the tip of the left temporal lobe. Magnetoencephalography demonstrated equivalent current dipoles located superiorly in the left temporal lobe. Our results suggest that the tip of the left temporal lobe plays an important role in the pathogenesis of LKS in our patient. |
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Authors:
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Hideaki Shiraishi; Kyoko Takano; Tohru Shiga; Maki Okajima; Akira Sudo; Naoko Asahina; Shinobu Kohsaka; Masakazu Fukuhara; Shinji Saitoh |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-03-26 |
Journal Detail:
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Title: Brain & development Volume: 29 ISSN: 0387-7604 ISO Abbreviation: Brain Dev. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-11-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 529-33 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hokkaido University, Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan. siraisi@med.hokudai.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use Child Electroencephalography Female Humans Landau-Kleffner Syndrome / metabolism*, pathology, physiopathology* Magnetic Resonance Imaging Magnetoencephalography Positron-Emission Tomography Seizures / drug therapy, etiology Technetium Tc 99m Exametazime Temporal Lobe / metabolism*, pathology, physiopathology* Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 100504-35-6/Technetium Tc 99m Exametazime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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