| Possible involvement of radical reactions in desialylation of LDL. | |
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MedLine Citation:
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PMID: 9280282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of oxidatively modified LDL in the pathogenesis of atherosclerosis has been well documented. These studies have focused on modifications of lipid and protein parts of LDL. Recently desialylated LDL has received attention in relation to atherosclerosis and coronary artery disease. We examined the possible involvement of radical reactions in desialylation of LDL. Human LDL was subjected to oxidative damage using Cu2+ ion. As the conjugated dienes monitored by absorption at 234 nm increased, the content of sialic acid decreased steadily. Both the elevation of conjugated diene and the decrease of sialic acid were inhibited by beta-mercaptoethanol, a typical radical scavenger. Besides, both butylated hydroxytoluene and a nitrogen atmosphere inhibited the decrease of sialic acid. These inhibition experiments suggested that sialic acid moieties in LDL were reactive toward radicals. |
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Authors:
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K Tanaka; S Tokumaru; S Kojo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 413 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-23 Completed Date: 1997-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 202-4 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, Nara Women's University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Butylated Hydroxytoluene
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pharmacology Copper Sulfate / pharmacology Free Radical Scavengers / pharmacology Free Radicals Humans Lipid Peroxidation Lipoproteins, LDL / metabolism* Mercaptoethanol / pharmacology N-Acetylneuraminic Acid / metabolism* Nitrogen / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Free Radicals; 0/Lipoproteins, LDL; 128-37-0/Butylated Hydroxytoluene; 131-48-6/N-Acetylneuraminic Acid; 60-24-2/Mercaptoethanol; 7727-37-9/Nitrogen; 7758-98-7/Copper Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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