Document Detail

Possible involvement of radical reactions in desialylation of LDL.
MedLine Citation:
PMID:  9280282     Owner:  NLM     Status:  MEDLINE    
The role of oxidatively modified LDL in the pathogenesis of atherosclerosis has been well documented. These studies have focused on modifications of lipid and protein parts of LDL. Recently desialylated LDL has received attention in relation to atherosclerosis and coronary artery disease. We examined the possible involvement of radical reactions in desialylation of LDL. Human LDL was subjected to oxidative damage using Cu2+ ion. As the conjugated dienes monitored by absorption at 234 nm increased, the content of sialic acid decreased steadily. Both the elevation of conjugated diene and the decrease of sialic acid were inhibited by beta-mercaptoethanol, a typical radical scavenger. Besides, both butylated hydroxytoluene and a nitrogen atmosphere inhibited the decrease of sialic acid. These inhibition experiments suggested that sialic acid moieties in LDL were reactive toward radicals.
K Tanaka; S Tokumaru; S Kojo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  413     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-23     Completed Date:  1997-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  202-4     Citation Subset:  IM    
Department of Food Science and Nutrition, Nara Women's University, Japan.
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MeSH Terms
Butylated Hydroxytoluene / pharmacology
Copper Sulfate / pharmacology
Free Radical Scavengers / pharmacology
Free Radicals
Lipid Peroxidation
Lipoproteins, LDL / metabolism*
Mercaptoethanol / pharmacology
N-Acetylneuraminic Acid / metabolism*
Nitrogen / pharmacology
Reg. No./Substance:
0/Free Radical Scavengers; 0/Free Radicals; 0/Lipoproteins, LDL; 128-37-0/Butylated Hydroxytoluene; 131-48-6/N-Acetylneuraminic Acid; 60-24-2/Mercaptoethanol; 7727-37-9/Nitrogen; 7758-98-7/Copper Sulfate

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