Document Detail

Possible involvement of queuine in regulation of cell proliferation.
MedLine Citation:
PMID:  18057548     Owner:  NLM     Status:  MEDLINE    
An increase in cell number is one of the most prominent characteristics of cancer cells. This may be caused by an increase in cell proliferation or decrease in cell death. Queuine is one of the modified base which is found at first anticodon position of specific tRNAs. It is ubiquitously present throughout the living system except mycoplasma and yeast. The tRNAs of Q-family are completely modified to Q-tRNAs in terminally differentiated somatic cells, however hypomodification of Q-tRNA is closely associated with cell proliferation and malignancy. Queuine participates at various cellular functions such as regulation of cell proliferation, cell signaling and alteration in the expression of growth associated proto-oncogenes. Like other proto-oncogenes bcl2 is known to involve in cell survival by inhibiting apoptosis. Queuine or Q-tRNA is suggested to inhibit cell proliferation but the mechanism of regulation of cell proliferation by queuine or Q-tRNA is not well understood. Therefore, in the present study regulation in cell proliferation by queuine in vivo and in vitro as well as the expression of cell death regulatory protein Bcl2 are investigated. For this DLAT cancerous mouse, U87 cell line and HepG2 cell line are treated with different concentrations of queuine and the effect of queuine on cell proliferation and apoptosis are studied. The results indicate that queuine down regulates cell proliferation and expression of Bcl2 protein, suggesting that queuine promotes cell death and participates in the regulation of cell proliferation.
Chandramani Pathak; Yogesh K Jaiswal; Manjula Vinayak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  29     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-73     Citation Subset:  IM    
School of Studies in Biochemistry, Jiwaji University, Gwalior, India.
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MeSH Terms
Apoptosis / drug effects
Body Weight / drug effects
Cell Death / drug effects
Cell Proliferation / drug effects*
Cell Survival / drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Down-Regulation / drug effects
Gene Expression Regulation / drug effects
Guanine / analogs & derivatives*,  pharmacology
Liver / drug effects
Lymphoma / drug therapy
Mice, Inbred AKR
Proto-Oncogene Proteins / drug effects,  metabolism
RNA, Transfer, Amino Acid-Specific / drug effects,  metabolism
Tumor Cells, Cultured
Reg. No./Substance:
0/Proto-Oncogene Proteins; 0/RNA, Transfer, Amino Acid-Specific; 114100-40-2/Bcl2 protein, mouse; 72496-59-4/queuine; 73-40-5/Guanine

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