Document Detail

Possible involvement of hypothyroidism as a cause of lithium-induced sinus node dysfunction.
MedLine Citation:
PMID:  10392396     Owner:  NLM     Status:  MEDLINE    
Although several reports have stated that even therapeutic levels of lithium can induce sinus node dysfunction, the mechanism has not been fully elucidated. We present here two patients with sinus node dysfunction after long-term lithium therapy. Following lithium discontinuation, sinus node function recovered completely. After resuming lithium, however, irreversible sinus node dysfunction recurred and a permanent pacemaker was implanted in one patient. The serum concentration of lithium was within therapeutic levels. Nevertheless, hypothyroidism was associated with the sinus node dysfunction in both patients. Thus, thyroid function may play an important role in sinus node dysfunction induced by lithium.
T Numata; H Abe; T Terao; Y Nakashima
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  22     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-08     Completed Date:  1999-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  954-7     Citation Subset:  IM    
Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
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MeSH Terms
Antimanic Agents / administration & dosage,  adverse effects*
Bipolar Disorder / drug therapy*
Dose-Response Relationship, Drug
Electrocardiography, Ambulatory / drug effects
Hypothyroidism / chemically induced*,  diagnosis
Lithium Carbonate / administration & dosage,  adverse effects*
Middle Aged
Sick Sinus Syndrome / chemically induced*,  diagnosis
Thyroid Function Tests
Reg. No./Substance:
0/Antimanic Agents; 554-13-2/Lithium Carbonate

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