Document Detail


Possible involvement of active oxygen species in selenite toxicity in isolated rat hepatocytes.
MedLine Citation:
PMID:  8239999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mechanisms of selenite cytotoxicity were examined using isolated rat hepatocytes. When selenite was added to a suspension of rat hepatocytes, intracellular reduced glutathione (GSH) was decreased and the oxygen consumption rate was increased. Subsequently, thiobarbituric acid-reactive substances (TBA-RS) and lactate dehydrogenase (LDH) leakage were increased. A ferric iron chelator, desferrioxamine (DF), and a synthetic superoxide dismutase (SOD) mimic, desferrioxamine manganese (DFMn), reduced the selenite toxicity. These results suggest that superoxide anion and its reactive metabolites such as the hydroxyl radical may be involved in the cytotoxicity of selenite.
Authors:
J Kitahara; Y Seko; N Imura
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives of toxicology     Volume:  67     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-12-21     Completed Date:  1993-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  497-501     Citation Subset:  IM    
Affiliation:
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Survival / drug effects
Drug Interactions
Glutathione / metabolism
Liver / cytology,  drug effects*
Male
Methylmercury Compounds / pharmacology
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species / pharmacology*
Sodium Selenite / toxicity*
Superoxide Dismutase / pharmacology
Chemical
Reg. No./Substance:
0/Methylmercury Compounds; 0/Reactive Oxygen Species; 10102-18-8/Sodium Selenite; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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