| Possible involvement of CD14(+) CD16(+) monocyte lineage cells in the epidermal damage of Stevens-Johnson syndrome and toxic epidermal necrolysis. | |
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MedLine Citation:
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PMID: 21936856 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by keratinocyte apoptosis and necrosis, resulting in epidermal detachment. Although monocytes abundantly infiltrate the epidermis in SJS/TEN skin lesions, the properties and functions of these cells have not been fully examined. Objectives: To determine the properties of monocytes infiltrating into the epidermis in SJS/TEN. Methods: Immunostaining of skin sections was performed to examine the membrane markers of monocytes infiltrating into skin lesions. Results: Immunostaining of cryo-sections from 11 SJS/TEN skin lesions revealed numerous CD14(+) monocytes located along the dermo-epidermal junction and throughout the epidermis. The cells co-expressed CD16, CD11c, and HLA-DR. CD14(+) CD16(+) cells were identified in very early lesions without epidermal damage, suggesting that their infiltration is a cause, rather than a result, of epidermal damage. Moreover, these cells expressed CD80, CD86, and CD137L, indicative of their ability to facilitate the proliferation and cytotoxicity of CD8 T cells. CD16(+) cells infiltrating the epidermis and detected at the dermo-epidermal junction were immunostained and counted in paraffin-embedded skin sections obtained from 47 patients with drug rash manifested as TEN, SJS, maculopapular-type rash, or erythema multiform-type rash. The number of CD16(+) monocytes infiltrating the epidermis increased significantly, depending on the grade of epidermal damage. Conclusions: These findings suggest that the appearance of CD14 (+) CD16 (+) cells of monocyte lineage play an important role in the epidermal damage associated with SJS/TEN, most likely by enhancing the cytotoxicity of CD8 T cells. |
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Authors:
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M Tohyama; H Watanabe; S Murakami; Y Shirakata; K Sayama; M Iijima; K Hashimoto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-21 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 British Association of Dermatologists. |
Affiliation:
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Department of Dermatology, Ehime University Graduate School of Medicine, Shitsukawa, Toon-city, Ehime 791-0295, Japan Department of Dermatology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. |
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