| Possible involvement of 4-hydroxynonenal in splenocyte regulated liver regeneration. | |
| | |
MedLine Citation:
|
PMID: 16403957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Liver regeneration is a complex, systemic process regulated by humoral and cellular mechanisms. Inflammatory response to the extensive tissue damage, as in partial hepatectomy, plays important role during regeneration. Hence, it is assumed that the spleen might play a role in systemic inflammatory response involved in liver regeneration. On the other hand, liver damage and consequential regeneration are often associated with oxidative stress and lipid peroxidation. One of the end products of lipid peroxidation, 4-hydroxynonenal (HNE), is nowadays considered not only as a "second toxic messenger of free radicals" but also as a growth-regulating factor. We therefore studied in vitro interactions of the HNE-treated murine liver cells and autologous spleen cells. The spleen cells supported recovery of liver cells from the HNE cytotoxicity although spleen cells themselves exerted cytotoxic effects against the proliferating liver cells that were not treated with HNE. Our results imply that the cytokines secreted by activated immunocompetent cells may be responsible for the observed recovery of the HNE-damage liver cells, suggesting that HNE might be an important factor regulating cellular and cytokine mediated mechanisms of liver regeneration control. |
| | |
Authors:
|
Ana Cipak; Suzana Borovic; Mira Scukanec-Spoljar; Iva Kirac; Neven Zarkovic |
Related Documents
:
|
1484157 - Can hepatocytes serve as 'activated' immunomodulating cells in the immune response? 12421677 - The role of cytokines in liver failure and regeneration: potential new molecular therap... 16276407 - B cells: no longer bystanders in liver fibrosis. 16911567 - Nomadic or sessile: can kupffer cells function as portals for malaria sporozoites to th... 12529427 - Caspase- and serine protease-dependent apoptosis by the death domain of fadd in normal ... 17488647 - Porcine reproductive and respiratory syndrome virus induces apoptosis through a mitocho... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: BioFactors (Oxford, England) Volume: 24 ISSN: 0951-6433 ISO Abbreviation: Biofactors Publication Date: 2005 |
Date Detail:
|
Created Date: 2006-01-11 Completed Date: 2006-05-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 217-26 Citation Subset: IM |
Affiliation:
|
Rudjer Boskovic Institute, Zagreb, Croatia. acipak@irb.hr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldehydes
/
pharmacology* Animals Cell Count Cell Survival Coculture Techniques DNA / biosynthesis Female Hepatocytes / metabolism, ultrastructure Lipid Peroxidation Liver / drug effects, metabolism, ultrastructure Liver Regeneration / drug effects* Microscopy, Electron Oxidative Stress Rats Rats, Wistar Spleen / cytology, physiology* Thymidine / metabolism Tritium |
| Chemical | |
Reg. No./Substance:
|
0/Aldehydes; 10028-17-8/Tritium; 29343-52-0/4-hydroxy-2-nonenal; 50-89-5/Thymidine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Daytime of sampling, tooth-brushing and ascorbic acid influence salivary thiobarbituric acid reactin...
Next Document: Total hydroxyoctadecadienoic acid as a marker for lipid peroxidation in vivo.