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Possible interaction between aspirin and ACE inhibitors: update on unresolved controversy.
MedLine Citation:
PMID:  12189336     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The widespread use of aspirin and angiotensin converting enzyme (ACE) inhibitors in patients with coronary artery disease contributes significantly to the reduction in morbidity and mortality from this common health problem. These agents are widely and concomitantly used, and they share mechanisms that may interact in negative or positive pathways. Data derived from in vitro preparations, animal studies, human studies, and case-control studies are inconsistent. No study has established firm evidence regarding the safety or adverse effect of aspirin on patients who are on ACE inhibitors. The efficacy and safety of aspirin in combination with ACE inhibitors has been questioned and debated. If a negative interaction does exist, it will affect daily practice in treating patients with coronary artery disease and heart failure. This article reviews the available data regarding the safety of combined aspirin and ACE-inhibitor treatment among patients with ischemic heart disease, to assess the possible interaction between the two drugs and to discuss the significance and implications of the data. (c)2000 by CHF, Inc.
Authors:
I M Barbash; U Goldbourt; S Gottlieb; S Behar; J Leor
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  6     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2002-Aug-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  313-318     Citation Subset:  -    
Affiliation:
Cardiology Department, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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