Document Detail


Possible inhibitory role of prolactin-releasing peptide for ACTH release associated with running stress.
MedLine Citation:
PMID:  16917019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise around the lactate threshold induces a stress response, defined as "running stress." We have previously demonstrated that running stress is associated with activation of certain regions of the brain, e.g., the paraventricular hypothalamic nucleus (PVN) and supraoptic nucleus, that are hypothesized to play an integral role in regulating stress-related responses, including ACTH release during running. Thus we investigated the role of prolactin-releasing peptide (PrRP), found in the ventrolateral medulla and the nucleus of the solitary tract, which is known to project to the PVN during running-induced ACTH release. Accumulation of c-Fos in PrRP neurons correlated with running speeds, reaching maximal levels under running stress. Intracerebroventricular injection of neutralizing anti-PrRP antibodies led to increased plasma ACTH level and blood lactate accumulation during running stress, but not during restraint stress. Exogenous intracerebroventricular administration of low doses of PrRP had the opposite effects. Therefore, our results suggest that, during running stress, PrRP-containing neurons are activated in an exercise intensity-dependent manner, and likewise the produced endogenous PrRP attenuates ACTH release and blood lactate accumulation during running stress. Here we provide a novel perspective on understanding of PrRP in the endocrine-metabolic response associated with running stress.
Authors:
Nao Ohiwa; Hyukki Chang; Tsuyoshi Saito; Tatsushi Onaka; Takahiko Fujikawa; Hideaki Soya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-17
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  292     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-02-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R497-504     Citation Subset:  IM    
Affiliation:
Laboratory of Exercise Biochemistry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / metabolism*
Animals
Blood Glucose / metabolism
Brain Chemistry / physiology
Hypothalamic Hormones / administration & dosage,  pharmacology,  physiology*
Immunohistochemistry
Injections, Intraventricular
Lactic Acid / blood
Male
Neurons / physiology
Neuropeptides / administration & dosage,  pharmacology,  physiology*
Oncogene Proteins v-fos / metabolism
Prolactin-Releasing Hormone
Rats
Rats, Wistar
Restraint, Physical
Running / physiology*
Stress, Physiological / metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hypothalamic Hormones; 0/Neuropeptides; 0/Oncogene Proteins v-fos; 0/PRLH protein, human; 0/Prlh protein, rat; 0/Prolactin-Releasing Hormone; 50-21-5/Lactic Acid; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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