Document Detail


Possible inhibition of hepatic metabolism of quinidine by erythromycin.
MedLine Citation:
PMID:  7828386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To present and analyze a patient case illustrating a possible drug interaction between quinidine and erythromycin. METHODS: This is a case report of one hospitalized patient. The setting for this analysis was a university hospital. Through a MEDLINE search of all English medical literature (1966 to 1994) documenting possible interactions between quinidine and erythromycin, retrospective patient chart review, and analysis of the relationship between serum quinidine concentrations and significant clinical events, deduce the possibility of a quinidine and erythromycin pharmacokinetic and pharmacodynamic interaction in this particular patient case. RESULTS: This case demonstrated a probable erythromycin-quinidine pharmacokinetic interaction that led to a decrease in quinidine apparent clearance, an increase in quinidine serum concentrations, and a possible quinidine toxicity. CONCLUSION: Serum quinidine concentrations, electrocardiograms, and other factors that may predispose patients to torsades de pointes, such as hypokalemia and hypomagnesemia, should be monitored closely if quinidine is coadministered with erythromycin.
Authors:
S A Spinler; J W Cheng; K E Kindwall; S L Charland
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  57     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-21     Completed Date:  1995-02-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  AIM; IM    
Affiliation:
Philadelphia College of Pharmacy and Science, PA 19104.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cytochrome P-450 Enzyme System / metabolism
Drug Interactions
Electrocardiography / drug effects
Erythromycin / pharmacology*
Humans
Liver / drug effects*,  enzymology,  metabolism*
Male
Metabolic Clearance Rate / drug effects
Quinidine / adverse effects,  metabolism*,  pharmacokinetics
Chemical
Reg. No./Substance:
114-07-8/Erythromycin; 56-54-2/Quinidine; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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