| Possible inhibition of hepatic metabolism of quinidine by erythromycin. | |
| | |
MedLine Citation:
|
PMID: 7828386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To present and analyze a patient case illustrating a possible drug interaction between quinidine and erythromycin. METHODS: This is a case report of one hospitalized patient. The setting for this analysis was a university hospital. Through a MEDLINE search of all English medical literature (1966 to 1994) documenting possible interactions between quinidine and erythromycin, retrospective patient chart review, and analysis of the relationship between serum quinidine concentrations and significant clinical events, deduce the possibility of a quinidine and erythromycin pharmacokinetic and pharmacodynamic interaction in this particular patient case. RESULTS: This case demonstrated a probable erythromycin-quinidine pharmacokinetic interaction that led to a decrease in quinidine apparent clearance, an increase in quinidine serum concentrations, and a possible quinidine toxicity. CONCLUSION: Serum quinidine concentrations, electrocardiograms, and other factors that may predispose patients to torsades de pointes, such as hypokalemia and hypomagnesemia, should be monitored closely if quinidine is coadministered with erythromycin. |
| | |
Authors:
|
S A Spinler; J W Cheng; K E Kindwall; S L Charland |
Related Documents
:
|
18314856 - A psychotic disorder related to use of herbal preparation: case report. 1178096 - Spinal neurinomas.--a comprehensive clinical and statistical study on 47 cases. 2606496 - Xecl laser in biliary calculus fragmentation: fluence threshold and ablation products. 2126406 - An atypical ultrastructural pattern in fabry's disease: a study on its nature and incid... 10874206 - Idiopathic juxtafoveolar retinal telangiectasia: a review and case report. 11522176 - The tessier number 5 cleft with associated extremity anomalies. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical pharmacology and therapeutics Volume: 57 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1995 Jan |
Date Detail:
|
Created Date: 1995-02-21 Completed Date: 1995-02-21 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 89-94 Citation Subset: AIM; IM |
Affiliation:
|
Philadelphia College of Pharmacy and Science, PA 19104. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cytochrome P-450 Enzyme System / metabolism Drug Interactions Electrocardiography / drug effects Erythromycin / pharmacology* Humans Liver / drug effects*, enzymology, metabolism* Male Metabolic Clearance Rate / drug effects Quinidine / adverse effects, metabolism*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
|
114-07-8/Erythromycin; 56-54-2/Quinidine; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lifibrol: a novel lipid-lowering drug for the therapy of hypercholesterolemia. Lifibrol Study Group.
Next Document: Pathological-radiological correlations in benign lesions excised during a breast screening programme...