| Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases. | |
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MedLine Citation:
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PMID: 15554769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Atypical antipsychotics are widely used in clinical practice for several psychiatric disorders. Between 1994 and 1999, 26 cases of manic and hypomanic syndromes were reported with olanzapine and risperidone and were described in a previous review article. METHOD: An updated MEDLINE search (1999-2003) using the terms atypical antipsychotics, amisulpride, aripiprazole, clozapine, flupenthixol, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, zotepine, hypomania, and mania showed that 34 new cases of induced hypomanic or manic syndromes have been published, not only with olanzapine (N = 5) and risperidone (N = 6), but also with quetiapine (N = 5) and ziprasidone (N = 11) treatment. Six cases have been reported with flupenthixol and 1 with amisulpride, two antipsychotics considered as "partial" atypicals. RESULTS: A critical analysis of these case reports revealed that the effects on mood were insufficiently documented in some of the reports but that for 20 of them, evidence is highly suggestive of a causative role of atypical antipsychotics in the induction of manic/hypomanic symptomatology. CONCLUSION: This updated review continues and extends the results of the initial review and suggests that atypical antipsychotics have some intriguing effects on mood. Such effects have never been reported with conventional antipsychotics. The mechanisms involved in this phenomenon of mood switch remain to be elucidated. |
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Authors:
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Fady Rachid; Gilles Bertschy; Guido Bondolfi; Jean-Michel Aubry |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 65 ISSN: 0160-6689 ISO Abbreviation: J Clin Psychiatry Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-23 Completed Date: 2004-12-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1537-45 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland. fady.rachid@hcuge.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antipsychotic Agents / adverse effects*, therapeutic use Benzodiazepines / adverse effects, therapeutic use Bipolar Disorder / chemically induced*, drug therapy Depressive Disorder, Major / drug therapy Female Humans Male Middle Aged Physician's Practice Patterns Practice Guidelines as Topic Psychotic Disorders / drug therapy Risperidone / adverse effects, therapeutic use Schizophrenia / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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