Document Detail

Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases.
MedLine Citation:
PMID:  15554769     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atypical antipsychotics are widely used in clinical practice for several psychiatric disorders. Between 1994 and 1999, 26 cases of manic and hypomanic syndromes were reported with olanzapine and risperidone and were described in a previous review article. METHOD: An updated MEDLINE search (1999-2003) using the terms atypical antipsychotics, amisulpride, aripiprazole, clozapine, flupenthixol, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, zotepine, hypomania, and mania showed that 34 new cases of induced hypomanic or manic syndromes have been published, not only with olanzapine (N = 5) and risperidone (N = 6), but also with quetiapine (N = 5) and ziprasidone (N = 11) treatment. Six cases have been reported with flupenthixol and 1 with amisulpride, two antipsychotics considered as "partial" atypicals. RESULTS: A critical analysis of these case reports revealed that the effects on mood were insufficiently documented in some of the reports but that for 20 of them, evidence is highly suggestive of a causative role of atypical antipsychotics in the induction of manic/hypomanic symptomatology. CONCLUSION: This updated review continues and extends the results of the initial review and suggests that atypical antipsychotics have some intriguing effects on mood. Such effects have never been reported with conventional antipsychotics. The mechanisms involved in this phenomenon of mood switch remain to be elucidated.
Fady Rachid; Gilles Bertschy; Guido Bondolfi; Jean-Michel Aubry
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  65     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2004-12-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1537-45     Citation Subset:  IM    
Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Benzodiazepines / adverse effects,  therapeutic use
Bipolar Disorder / chemically induced*,  drug therapy
Depressive Disorder, Major / drug therapy
Middle Aged
Physician's Practice Patterns
Practice Guidelines as Topic
Psychotic Disorders / drug therapy
Risperidone / adverse effects,  therapeutic use
Schizophrenia / drug therapy
Reg. No./Substance:
0/Antipsychotic Agents; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine

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