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Possible in vivo tolerance of human polymorphonuclear neutrophil to low-grade exercise-induced endotoxaemia.
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MedLine Citation:
PMID:  9927234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To address the question of whether translocation of bacterial lipopolysaccharide (LPS) into the blood could be involved in the process of exercise-induced polymorphonuclear neutrophil (PMN) activation, 12 healthy male subjects who took part in a sprint triathlon (1.5 km river swim, 40 km bicycle race, 10 km road race) were studied. While there was no detectable amount of endotoxin in the blood samples drawn at rest, exercise was followed by the appearance of circulating endotoxin molecules at the end of competition in four subjects, and after one and 24 h recovery in three and seven athletes, respectively. The concentrations of plasma granulocyte myeloperoxidase ([MPO]), were significantly higher immediately after exercise and one hour later-than baseline values (P<0.001). This variable returned to pre-race levels the day after exercise, despite the presence of detectable amounts of LPS, at that time, in seven athletes. The absence of significant correlation (r=0.26; P=0.383) and temporal association between [MPO] and plasma endotoxin levels led us to conclude that endotoxaemia was not involved in the process of exercise-induced PMN degranulation observed in our subjects.
Authors:
G Camus; M Nys; J R Poortmans; I Venneman; T Monfils; G Deby-Dupont; A Juchmès-Ferir; C Deby; M Lamy; J Duchateau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mediators of inflammation     Volume:  7     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  1998  
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  413-5     Citation Subset:  IM    
Affiliation:
Institute of Chemistry, University of Liège, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Endotoxemia / immunology*
Exercise*
Humans
Lipopolysaccharides / metabolism
Male
Neutrophils / immunology*
Peroxidase / metabolism
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; EC 1.11.1.7/Peroxidase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
Article Information
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Print publication date: Year: 1998
Volume: 7 Issue: 6
First Page: 413 Last Page: 415
ID: 1781869
PubMed Id: 9927234

Possible in vivo tolerance of human polymorphonuclear neutrophil to low-grade exercise-induced endotoxaemia.
G Camus
M Nys
J R Poortmans
I Venneman
T Monfils
G Deby-Dupont
A Juchm?s-Ferir
C Deby
M Lamy
J Duchateau
Institute of Chemistry, University of Li?ge, Belgium.


Article Categories:
  • Research Article


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