Document Detail

Possible improvement in uteroplacental blood flow during atrial natriuretic peptide infusion in preeclampsia.
MedLine Citation:
PMID:  8041537     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effects of low doses of the hormone atrial natriuretic peptide (ANP) on uteroplacental blood flow in patients with preeclampsia. METHODS: Eleven women with preeclampsia were infused intravenously with ANP (10 ng/kg/minute). Uteroplacental blood flow index was measured using dynamic placental scintigraphy with indium-113m. Regional blood flows were assessed by pulsed Doppler ultrasound and expressed as pulsatility index (PI). Hemodynamic measurements and blood sampling for peripheral venous plasma analysis of cyclic guanosine monophosphate (cGMP), an ANP second messenger, were performed before and after 30 minutes of infusion. Nonparametric statistics were used. RESULTS: The uteroplacental blood flow index increased by 28% (-2 to 58%; mean and 95% confidence interval). The Doppler findings were unaffected. Mean arterial blood pressure decreased from 112 (108-117) to 108 (103-114) mmHg (P < .01). Cyclic GMP increased significantly from 9.2 (6.2-12.3) to 17.4 (12.3-22.6) nmol/L (P < .01). Subjects exhibiting a substantial increase in uteroplacental blood flow index (25% or more) demonstrated a significantly greater cGMP response (P < .01) than those who did not (6% or less increase). CONCLUSION: A tendency to an increased uteroplacental blood flow index combined with minor blood pressure reduction after ANP infusion suggest the possibility of uteroplacental vasodilatation.
C Grunewald; H Nisell; T Jansson; M Kublickas; S Thornström; L Nylund
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  84     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-08-25     Completed Date:  1994-08-25     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Huddinge University Hospital, Sweden.
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MeSH Terms
5'-Guanylic Acid / blood
Atrial Natriuretic Factor / administration & dosage*
Blood Flow Velocity / drug effects*,  physiology
Blood Pressure / drug effects,  physiology
Indium Radioisotopes / diagnostic use
Infusions, Intravenous
Maternal-Fetal Exchange / drug effects*,  physiology
Placenta / blood supply,  radionuclide imaging,  ultrasonography
Pre-Eclampsia / blood,  drug therapy*,  physiopathology
Pulsatile Flow
Regional Blood Flow / drug effects,  physiology
Ultrasonography, Prenatal
Uterus / blood supply,  radionuclide imaging,  ultrasonography
Vasodilation / drug effects*,  physiology
Reg. No./Substance:
0/Indium Radioisotopes; 85-32-5/5'-Guanylic Acid; 85637-73-6/Atrial Natriuretic Factor
Comment In:
Obstet Gynecol. 1995 Jan;85(1):156-7   [PMID:  7865013 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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