Document Detail

Possible genotoxic activity of extracts of Bryonia alba roots on human lymphocytes and transformed cells.
MedLine Citation:
PMID:  12088103     Owner:  NLM     Status:  MEDLINE    
Bryonia alba roots (BAR) are widely used as an adaptogenic and restorative drug with immunomodulatory and stress-protective properties that increase the non-specific resistance of an organism toward harmful stimuli. Potential genotoxic activity of aqueous and methanol extracts of BAR was studied on human normal (lymphocytes) and transformed (HeLa and Caco-2) cells using single cell gel electrophoresis (the comet assay). The results obtained did not show any evidence of genotoxic effects of BAR.
A K Nersesyan; A R Collins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neoplasma     Volume:  49     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-28     Completed Date:  2002-07-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  114-6     Citation Subset:  IM    
Laboratory of Carcinogenesis, Cancer Research Center, Yerevan, Armenia.
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MeSH Terms
Cell Survival / drug effects*
Cell Transformation, Neoplastic / drug effects*
DNA Damage*
Hela Cells
Lymphocytes / drug effects*
Mutagens / toxicity
Plant Extracts / toxicity*
Plant Roots*
Tumor Cells, Cultured
Reg. No./Substance:
0/Mutagens; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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