Document Detail

Possible formation of nitrosamine in guinea pigs following exposure to nitrogen dioxide and dimethylamine.
MedLine Citation:
PMID:  7265307     Owner:  NLM     Status:  MEDLINE    
The possibility of formation of nitrosamine was investigated in animals exposed to a combination of dimethylamine (DMA) and NO2. First, the distribution and covalent binding of DMA and dimethylnitrosamine (DMN) in rats and guinea pigs were determined. The apparent volume of distribution and biological half-life for [14C]-DMA or [14C]DMN did not reveal any species difference. In general, there were no marked differences in accumulation of radioactivity in tissues of guinea pigs and rats 4 h after the administration of DMA, while the guinea pig tissues showed higher accumulation after DMN administration. Nucleic acid fractions prepared from liver and lungs of both species following administration of DMN or DMA in vivo showed much higher covalent binding with DMN than with DMA. Furthermore, the covalent binding of DMN was found to be due to bioactivation, whereas the DMA binding was nonspecific. Since guinea pig liver showed a higher degree of covalent binding than rat liver, this species was used to investigate the possible increase in covalent binding in the presence of NO2 and DMA as a reflection of DMN formation. There was no evidence of enhancement of covalent binding when animals pretreated with [14C]-DMA were exposed for various lengths of time to different concentrations of NO2.
A Chaudhari; S Dutta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  7     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  753-63     Citation Subset:  IM    
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MeSH Terms
Carbon Radioisotopes
DNA / metabolism
Dimethylamines / metabolism*
Dimethylnitrosamine / metabolism*
Guinea Pigs
Nitrogen Dioxide / metabolism*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Dimethylamines; 10102-44-0/Nitrogen Dioxide; 62-75-9/Dimethylnitrosamine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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