Document Detail


Possible endocrine disrupting effects of parabens and their metabolites.
MedLine Citation:
PMID:  20381602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parabens are preservatives used in a wide range of cosmetic products, including products for children, and some are permitted in foods. However, there is concern for endocrine disrupting effects. This paper critically discusses the conclusions of recent reviews and original research papers and provides an overview of studies on toxicokinetics. After dermal uptake, parabens are hydrolyzed and conjugated and excreted in urine. Despite high total dermal uptake of paraben and metabolites, little intact paraben can be recovered in blood and urine. Paraben metabolites may play a role in the endocrine disruption seen in experimental animals and studies are needed to determine human levels of parabens and metabolites. Overall, the estrogenic burden of parabens and their metabolites in blood may exceed the action of endogenous estradiol in childhood and the safety margin for propylparaben is very low when comparing worst-case exposure to NOAELs from experimental studies in rats and mice.
Authors:
Julie Boberg; Camilla Taxvig; Sofie Christiansen; Ulla Hass
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-08
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  30     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-11-16     Revised Date:  2011-09-07    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-12     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
National Food Institute, Technical University of Denmark, Division of Toxicology and Risk Assessment, Søborg, Denmark. jubo@food.dtu.dk
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Endocrine Disruptors / classification,  pharmacokinetics,  toxicity*
Environmental Exposure / adverse effects*
Environmental Pollutants / classification,  pharmacokinetics,  toxicity*
Estradiol / physiology
Humans
Mice
No-Observed-Adverse-Effect Level
Parabens / classification,  pharmacokinetics,  toxicity*
Preservatives, Pharmaceutical / classification,  pharmacokinetics,  toxicity*
Rats
Risk Assessment
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 0/Environmental Pollutants; 0/Parabens; 0/Preservatives, Pharmaceutical; 50-28-2/Estradiol
Comments/Corrections
Comment In:
Reprod Toxicol. 2011 Jul;32(1):138-40; author reply 141   [PMID:  21440055 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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