Document Detail

Possible effects of androgens on Islet Cell Functions.
MedLine Citation:
PMID:  19261392     Owner:  NLM     Status:  MEDLINE    
Previous studies show that hypogonadism is associated with a higher incidence of type 2 diabetes in male patients, in contrast, hyperandrogenism is associated with higher risk of type 2 diabetes in women. We hypothesized that there androgens may have negative effects on beta-cell functions. Androgen receptors may be important for function of beta cells. Androgen replacement may increase beta cell dysfunction and antiandrogen treatment may restore beta cell dysfunction in patients with polycystic ovary syndrome (PCOS). Also androgen receptors may be new era for Islet Cell transplantation. Researches in patients with PCOS and hypogonadism are necessary to test this hypothesis.
Mustafa Sahin; Tuncay Delibasi
Publication Detail:
Type:  Journal Article     Date:  2009-03-03
Journal Detail:
Title:  Medical hypotheses     Volume:  72     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  711-2     Citation Subset:  IM    
Department of Endocrinology and Metabolism, Gaziantep State Hospital (Mandatory Duity), Gaziantep, Turkey.
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MeSH Terms
Androgens / metabolism*,  pharmacology*
Islets of Langerhans / drug effects,  metabolism*
Models, Biological*
Receptors, Androgen / metabolism*
Reg. No./Substance:
0/Androgens; 0/Receptors, Androgen

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