Document Detail


Possible early prediction of preterm birth by determination of novel proinflammatory factors in midtrimester amniotic fluid.
MedLine Citation:
PMID:  17308171     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interferon-gamma-inducible T cell-alpha chemoattractant (ITAC) is a chemokine, directing activated T lymphocytes toward sites of inflammation. ADAM-8 (A disintegrin and metalloprotease-8) is a glycoprotein expressed in cells promoting inflammation. Elastase, a protease targeting at the degradation of intra- or extracellular proteins, is inhibited by secretory leukocyte proteinase inhibitor (SLPI), which protects against microbial invasion. Adhesion molecules (soluble intercellular adhesion molecule--sICAM-1 and soluble vascular cell adhesion molecule-sVCAM--1) serve as markers of inflammation or tissue damage. We hypothesized that elevated midtrimester amniotic fluid concentrations of above substances, and decreased levels of SLPI could possibly be useful predictors of asymptomatic intra-amniotic inflammation and/or infection, eventually resulting in preterm labor and delivery. The study involved 312 women undergoing midtrimester amniocentesis. Thirteen cases, progressing to preterm delivery (<37 weeks), were matched with 21 controls (delivering >37 weeks) for age, parity, and gestational age at amniocentesis. Amniotic fluid levels of the above substances were measured by enzyme-linked immunosorbent assay (ELISA). Only amniotic fluid ITAC and ADAM-8 levels were significantly higher (P=0.005 and P < 0.02, respectively) in women delivering at <37 weeks than at >37 weeks. SLPI concentrations significantly increased in women going into labor without ruptured membranes irrespective of pre- or term delivery (P < 0.007, P < 0.001, respectively) and correlated with elastase (r=0.508, P < 0.002). In conclusion, elevated midtrimester amniotic fluid levels of ITAC and ADAM-8 could predict occult infections/inflammations, possibly resulting in preterm birth.
Authors:
Ariadne Malamitsi-Puchner; Nikolaos Vrachnis; Evi Samoli; Stavroula Baka; Zoe Iliodromiti; Karl-Philipp Puchner; Pantelis Malligianis; Dimitrios Hassiakos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1092     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-04-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-9     Citation Subset:  IM    
Affiliation:
Second Department of Obstetrics and Gynecology, University of Athens, 19, Soultani Str., GR-10682 Athens, Greece. malamitsi@aias.gr
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MeSH Terms
Descriptor/Qualifier:
ADAM Proteins
Adult
Amniotic Fluid / metabolism*
Benzoates / metabolism*
Biphenyl Compounds / metabolism*
Case-Control Studies
Chemokine CXCL11
Chemokines, CXC / metabolism*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Membrane Proteins
Obstetric Labor, Premature / diagnosis*
Pregnancy
Pregnancy Trimester, Second
Prenatal Diagnosis*
Chemical
Reg. No./Substance:
0/Benzoates; 0/Biphenyl Compounds; 0/CXCL11 protein, human; 0/Chemokine CXCL11; 0/Chemokines, CXC; 0/Membrane Proteins; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAM8 protein, human

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