Document Detail


Possible dual roles for prostacyclin in human pregnancy and labor.
MedLine Citation:
PMID:  19033650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During pregnancy, the muscular layer of the uterine wall known as the myometrium, which is composed mainly of smooth muscle cells, is maintained in a state of relative quiescence. A switch from myometrial quiescence to myometrial activation is required to establish uterine contractions during labor. Researchers have long been perplexed by the fact that the major prostaglandin produced by the uterus just prior to labor, prostacyclin, is a smooth muscle relaxant. In this issue of the JCI, Fetalvero et al. provide data that they propose explains this paradox, at least in part (see the related article beginning on page 3966). The authors examined uterine tissue from pregnant women near term and found that prostacyclin stimulation, which raises cAMP levels that were previously thought to affect only myometrial quiescence, can promote myometrial activation over time by increasing the expression of a select group of proteins thought to be indicative of a uterine contractile state.
Authors:
Michael J Taggart; G Nicholas Europe-Finner; Bryan F Mitchell
Publication Detail:
Type:  Comment; Journal Article     Date:  2008-11-20
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  118     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2008-12-30     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3829-32     Citation Subset:  AIM; IM    
Affiliation:
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Michael.taggart@ncl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Connexin 43 / metabolism
Cyclic AMP / metabolism
Cyclic AMP-Dependent Protein Kinases / metabolism
Cyclooxygenase 2 / biosynthesis
Epoprostenol / metabolism*,  pharmacology
Female
Gap Junctions / metabolism
Humans
Myometrium / metabolism*
Oxytocics / pharmacology
Oxytocin / pharmacology
Parturition / drug effects,  physiology*
Pregnancy / drug effects,  physiology*
Receptors, Epoprostenol / metabolism
Signal Transduction / drug effects,  physiology*
Up-Regulation / drug effects,  physiology
Uterine Contraction / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Connexin 43; 0/Oxytocics; 0/Receptors, Epoprostenol; 35121-78-9/Epoprostenol; 50-56-6/Oxytocin; 60-92-4/Cyclic AMP; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases
Comments/Corrections
Comment On:
J Clin Invest. 2008 Dec;118(12):3966-79   [PMID:  19033666 ]

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