| Possible dual roles for prostacyclin in human pregnancy and labor. | |
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MedLine Citation:
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PMID: 19033650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During pregnancy, the muscular layer of the uterine wall known as the myometrium, which is composed mainly of smooth muscle cells, is maintained in a state of relative quiescence. A switch from myometrial quiescence to myometrial activation is required to establish uterine contractions during labor. Researchers have long been perplexed by the fact that the major prostaglandin produced by the uterus just prior to labor, prostacyclin, is a smooth muscle relaxant. In this issue of the JCI, Fetalvero et al. provide data that they propose explains this paradox, at least in part (see the related article beginning on page 3966). The authors examined uterine tissue from pregnant women near term and found that prostacyclin stimulation, which raises cAMP levels that were previously thought to affect only myometrial quiescence, can promote myometrial activation over time by increasing the expression of a select group of proteins thought to be indicative of a uterine contractile state. |
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Authors:
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Michael J Taggart; G Nicholas Europe-Finner; Bryan F Mitchell |
Publication Detail:
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Type: Comment; Journal Article Date: 2008-11-20 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 118 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-26 Completed Date: 2008-12-30 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 3829-32 Citation Subset: AIM; IM |
Affiliation:
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Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Michael.taggart@ncl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Connexin 43 / metabolism Cyclic AMP / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Cyclooxygenase 2 / biosynthesis Epoprostenol / metabolism*, pharmacology Female Gap Junctions / metabolism Humans Myometrium / metabolism* Oxytocics / pharmacology Oxytocin / pharmacology Parturition / drug effects, physiology* Pregnancy / drug effects, physiology* Receptors, Epoprostenol / metabolism Signal Transduction / drug effects, physiology* Up-Regulation / drug effects, physiology Uterine Contraction / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Oxytocics; 0/Receptors, Epoprostenol; 35121-78-9/Epoprostenol; 50-56-6/Oxytocin; 60-92-4/Cyclic AMP; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2008 Dec;118(12):3966-79
[PMID:
19033666
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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