| Possible cellular and molecular mechanisms for asbestos carcinogenicity. | |
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MedLine Citation:
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PMID: 1536158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asbestos fibers may exert their carcinogenic effects on mesothelial cells and bronchial epithelial cells by direct and indirect mechanisms. Direct effects can occur following the physical interaction of fibers with target cells or by the generation of free radicals from the fiber surface; indirect effects, following the interaction of fibers with inflammatory cells can result in the production of cellular mediators such as cytokines and various reactive oxygen species. As a result, target cells may be induced to proliferate and/or sustain genetic alterations, which lead to tumor development. |
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Authors:
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C Walker; J Everitt; J C Barrett |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of industrial medicine Volume: 21 ISSN: 0271-3586 ISO Abbreviation: Am. J. Ind. Med. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-03-23 Completed Date: 1992-03-23 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 8101110 Medline TA: Am J Ind Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-73 Citation Subset: IM |
Affiliation:
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Chemical Industry Institute for Toxicology, Research Triangle Park, North Carolina 27709. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asbestos / adverse effects*, metabolism Carcinoma, Bronchogenic / etiology*, genetics Cell Transformation, Neoplastic / chemically induced, genetics Chromosome Aberrations / chemically induced Chromosome Disorders Cricetinae Growth Substances / metabolism Humans Mesocricetus Mesothelioma / etiology*, genetics Mutation Oxidants / metabolism Rats Smoking / adverse effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 0/Oxidants; 1332-21-4/Asbestos |
| Comments/Corrections | |
Comment In:
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Am J Ind Med. 1992;21(2):137-9
[PMID:
1536150
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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