Document Detail

Possible carcinogenic risks of copper gluconate and their prevention by co-administered green tea catechins evaluated by a rat medium-term multi-organ carcinogenicity bioassay protocol.
MedLine Citation:
PMID:  18313194     Owner:  NLM     Status:  MEDLINE    
Carcinogenic risks of copper gluconate, green tea catechins and their combined exposure were evaluated using a rat medium-term multi-organ carcinogenicity bioassay protocol. Male BrlHan:WIST@Jcl (GALAS) rats were given N-nitrosodiethylamine (DEN), N-methylnitrosourea (MNU), 1,2-dimethylhydrazine (DMH), N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) and 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN) for a total multiple initiation period of 4 weeks (DMBDD treatment). Rats were then given a diet containing copper gluconate at a concentration of 0, 10, 300, 3000 or 6000 ppm with or without a co-administration of catechins starting 1 week later by admixing in the drinking water at a concentration of 5000 ppm. All survivors were sacrificed at the end of week 29. Number of putatively preneoplastic, glutathione S-transferase placental form-positive, liver lesions significantly increased by copper gluconate of 300 ppm or greater. In addition, both incidence and grade of hyperplasia in the forestomach significantly increased by copper gluconate of 6000 ppm. Catechins, exerting no effects by themselves, inhibited these effects of copper gluconate. The present results indicate that copper gluconate may possess carcinogenic risks for the liver and forestomach at its high dose level, and that co-administered green tea catechins may exert preventive effects.
Masayoshi Abe; Noriko Suzuki; Midori Yoshida; Koji Usuda; Satoshi Furukawa; Lekh Raj Juneja; Tsutomu Okubo; Dai Nakae
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-21
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-03-24     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1760-70     Citation Subset:  IM    
Toxicology and Environmental Science Department, Biological Research Laboratories, Nissan Chemical Industries, Limited, Minamisaitama, Saitama, Japan.
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MeSH Terms
Anticarcinogenic Agents*
Body Weight / drug effects
Carcinogenicity Tests
Carcinogens / antagonists & inhibitors*,  toxicity*
Catechin / pharmacology*
Copper / metabolism
Drinking / drug effects
Gluconates / antagonists & inhibitors*,  toxicity*
In Situ Nick-End Labeling
Liver / metabolism
Organ Size / drug effects
Rats, Wistar
Tea / chemistry*
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Carcinogens; 0/Gluconates; 0/Tea; 154-23-4/Catechin; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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