Document Detail

Possible association of sudden infant death with partial complement C4 deficiency revealed by post-mortem DNA typing of HLA class II and III genes.
MedLine Citation:
PMID:  2612504     Owner:  NLM     Status:  MEDLINE    
Based on evidence of an increased rate of respiratory infections in sudden infant death (SID) infants as well as the observation of familial occurrence, we analysed in a retrospective study class II and class II genes of the major histocompatibility complex in 40 cases of SID by Southern blot analysis of DNA obtained post mortem from tissue samples. In 24 cases, the parents were interviewed and confirmatory human lymphocyte antigen (HLA) and DNA typing was carried out. Using HLA-DR beta and -DQ beta probes, no evidence of an abnormal HLA-DR frequency distribution in SID infants was detected (P = 0.97). Using DNA probes for the tandemly arranged complement C4 and steroid 21-hydroxylase genes, an increased number of C4B gene deletions in SID cases was found. The increase in C4 gene deletions was significant (P = 0.0125) in infants with recurrent infections. These data indicate a possible role of partial C4 deficiency as a genetically predisposing risk factor in SID.
P M Schneider; C Wendler; T Riepert; L Braun; U Schacker; M Horn; H Althoff; R Mattern; C Rittner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pediatrics     Volume:  149     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-12     Completed Date:  1990-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  170-4     Citation Subset:  IM    
Institut für Rechtsmedizin der Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany.
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MeSH Terms
Complement C4 / analysis,  deficiency*,  genetics
Germany, West / epidemiology
HLA-DR Antigens / analysis,  genetics*,  immunology
Respiratory Tract Infections / complications*,  genetics,  immunology
Retrospective Studies
Risk Factors
Sudden Infant Death / epidemiology,  etiology*
Reg. No./Substance:
0/Complement C4; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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