| Possible association of lower rate of postherpetic neuralgia in patients on anti-tumor necrosis factor-α. | |
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MedLine Citation:
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PMID: 21915882 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recently, a study of patients with rheumatoid arthritis who developed herpes zoster while taking a tumor necrosis factor (TNF)-α inhibitor reported a decreased incidence of postherpetic neuralgia. The objective of this study was to investigate whether patients on TNF-α inhibitors who developed herpes zoster have a lower incidence of subsequent development of postherpetic neuralgia. A retrospective review of herpes zoster patients on TNF-α inhibitors (infliximab, etanercept, or adalimumab) was conducted in 12 dermatology clinics. Medical records of such patients were reviewed thoroughly to confirm herpes zoster and TNF-α inhibitors and any subsequent development of postherpetic neuralgia (pain score ≥3 out of 10 after 90 days of shingles onset) was noted. A total of 206 cases were reviewed, of which only 2 cases (<1%) developed postherpetic neuralgia, a considerably lower incidence rate than noted in the literature. Increasing age is a known risk factor in the development of postherpetic neuralgia. However, of the 58 (28.1%) cases ≥70 years of age, only 1 patient (1.7%) developed neuralgia compared to approximately 50% of patients who develop postherpetic neuralgia in this age group as reported in the literature. Treatment with TNF-α inhibitors may be associated with a lower incidence of postherpetic neuralgia but further prospective large-scale studies are needed to confirm this data. J. Med. Virol. 83:2051-2055, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Saba Javed; Qurat-Ul-Ain Kamili; Natalia Mendoza; Stephen K Tyring |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical virology Volume: 83 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
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Languages: eng Pagination: 2051-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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University of Texas Medical School at Houston, Houston, Texas. sabajaved23@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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