Document Detail

Possible association of influenza A with fetal loss: investigation of a cluster of spontaneous abortions and stillbirths.
MedLine Citation:
PMID:  7513232     Owner:  NLM     Status:  MEDLINE    
It has been suspected that influenza infection is associated with fetal or perinatal mortality, but little recent evidence supports this hypothesis. A small cluster of early and late fetal deaths in early 1986 prompted an epidemiological investigation. Women whose pregnancies were affected (cases) were compared with women whose pregnancies had a normal outcome (controls). Case pregnancies were distinguished by a significant excess of recent flu-like illness (p = 0.006), and were significantly more likely than controls to have serological evidence of influenza A infection (p = 0.00067), predominantly the influenza A H3N2, Christchurch/4/85-like strain. The cluster was recognised because most cases were patients of one health centre. Larger epidemiological studies will be needed to confirm an association between influenza A and fetal death, but this cluster suggests that influenza A may have an adverse influence on fetal survival.
R Stanwell-Smith; A M Parker; P Chakraverty; N Soltanpoor; C N Simpson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Communicable disease report. CDR review     Volume:  4     ISSN:  1350-9349     ISO Abbreviation:  Commun Dis Rep CDR Rev     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-02     Completed Date:  1994-06-02     Revised Date:  2005-11-22    
Medline Journal Info:
Nlm Unique ID:  9312372     Medline TA:  Commun Dis Rep CDR Rev     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  R28-32     Citation Subset:  IM    
PHLS Communicable Disease Surveillance Centre, London.
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MeSH Terms
Abortion, Spontaneous / etiology*
Cluster Analysis
England / epidemiology
Fetal Death / etiology*
Influenza A virus*
Influenza, Human / complications*,  epidemiology
Pregnancy Complications, Infectious* / epidemiology
Wales / epidemiology

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