Document Detail

Possible association between IgG4-associated systemic disease with or without autoimmune pancreatitis and non-Hodgkin lymphoma.
MedLine Citation:
PMID:  19258916     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: IgG4-associated systemic disease (ISD) is a multiorgan fibroinflammatory disorder whose pancreatic manifestation is called autoimmune pancreatitis (AIP). We describe 3 patients who developed non-Hodgkin lymphoma during the follow-up of ISD. METHODS: At our institution's pancreas clinic, we have prospectively and retrospectively examined patients with ISD with (n = 101) or without (n = 10) AIP (mean age, 59 years; 90 males and 21 females). We reviewed the medical records of all 111 patients to identify patients who developed non-Hodgkin lymphoma during the follow-up since their first presentation of ISD. Standardized incidence rate was calculated. RESULTS: The 111 patients with ISD with or without AIP had 331 patient-years of observation during which 3 patients had a diagnosis of non-Hodgkin lymphoma 3 to 5 years after the diagnosis of ISD. In these patients who later developed lymphoma, ISD involved the pancreas (AIP) in 2 and salivary gland in 1. Non-Hodgkin lymphoma had extranodal involvement in all patients (liver [n = 2], adrenal glands [n=1], kidney [n= 1], and lung [n = 1]). Standardized incidence rate was 16.0 (95% confidence interval, 3.3-45.5). CONCLUSIONS: We report 3 cases of non-Hodgkin lymphoma that developed during the follow-up of ISD suggesting that patients with ISD may be at an increased risk of developing non-Hodgkin lymphoma.
Naoki Takahashi; Amaar H Ghazale; Thomas C Smyrk; Jayawant N Mandrekar; Suresh T Chari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  38     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-24     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-6     Citation Subset:  IM    
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Aged, 80 and over
Autoimmune Diseases / complications*,  immunology
Follow-Up Studies
Immunoglobulin G / immunology*
Lymphoma, Non-Hodgkin / diagnosis,  etiology*
Middle Aged
Pancreatitis / complications*,  immunology
Risk Factors
Tomography, X-Ray Computed
Young Adult
Reg. No./Substance:
0/Immunoglobulin G

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