Document Detail

Possible association of benzalkonium chloride in nebulizer solutions with respiratory arrest.
MedLine Citation:
PMID:  1611157     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of possible association of benzalkonium chloride in nebulizer solutions with respiratory arrest and to review the involvement of various preservative agents in paradoxical bronchoconstrictive reactions. DATA SOURCES: Reference articles, case reports, and editorials are identified in the text. DATA SYNTHESIS: Many pharmacologic agents are available for nebulization. In addition to the active drug, these nebulizer solutions may contain preservatives. We describe a case of respiratory arrest in a 64-year-old man following nebulization therapy with albuterol and ipratropium solutions. These solutions contain benzalkonium chloride as a preservative. We are aware of only one report describing two deaths associated with such a severe reaction attributable to nebulization therapy. However, many reports of milder paradoxical bronchoconstriction are available in the medical literature. CONCLUSIONS: Clinicians should be aware of the possibility of paradoxical bronchoconstrictive reactions when patients are treated with nebulized bronchodilators.
M Boucher; M T Roy; J Henderson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  26     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-29     Completed Date:  1992-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  772-4     Citation Subset:  IM    
Pulmonary and Internal Medicine, Ottawa General Hospital, Ontario, Canada.
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MeSH Terms
Benzalkonium Compounds / adverse effects*
Middle Aged
Nebulizers and Vaporizers
Respiratory Insufficiency / chemically induced*
Solutions / standards
Reg. No./Substance:
0/Benzalkonium Compounds; 0/Solutions

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