| Possible association of benzalkonium chloride in nebulizer solutions with respiratory arrest. | |
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MedLine Citation:
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PMID: 1611157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of possible association of benzalkonium chloride in nebulizer solutions with respiratory arrest and to review the involvement of various preservative agents in paradoxical bronchoconstrictive reactions. DATA SOURCES: Reference articles, case reports, and editorials are identified in the text. DATA SYNTHESIS: Many pharmacologic agents are available for nebulization. In addition to the active drug, these nebulizer solutions may contain preservatives. We describe a case of respiratory arrest in a 64-year-old man following nebulization therapy with albuterol and ipratropium solutions. These solutions contain benzalkonium chloride as a preservative. We are aware of only one report describing two deaths associated with such a severe reaction attributable to nebulization therapy. However, many reports of milder paradoxical bronchoconstriction are available in the medical literature. CONCLUSIONS: Clinicians should be aware of the possibility of paradoxical bronchoconstrictive reactions when patients are treated with nebulized bronchodilators. |
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Authors:
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M Boucher; M T Roy; J Henderson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 26 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-07-29 Completed Date: 1992-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 772-4 Citation Subset: IM |
Affiliation:
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Pulmonary and Internal Medicine, Ottawa General Hospital, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Benzalkonium Compounds
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adverse effects* Humans Male Middle Aged Nebulizers and Vaporizers Respiratory Insufficiency / chemically induced* Solutions / standards |
| Chemical | |
Reg. No./Substance:
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0/Benzalkonium Compounds; 0/Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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