Document Detail

Possible association of CEA expression with oxyphilic change but not with C-cell hyperplasia in Hashimoto's thyroiditis.
MedLine Citation:
PMID:  20616436     Owner:  NLM     Status:  MEDLINE    
Reactive C-cell hyperplasia (CCH) has been observed in cases of autoimmune Hashimoto's thyroiditis; however, its occurrence in Graves' disease, the other major autoimmune disorder, has not yet been investigated. On the other hand, although Carcinoembryonic Antigen (CEA) serum levels have been reported elevated in patients with autoimmune thyroid disease (ATD), the source of CEA production at the cellular level is not elucidated. The aim of this study was to evaluate CCH and CEA immunohistochemical expression and comparatively analyze them in 136 ATD cases (107 Hashimoto's and 29 Graves' disease cases) and 20 cases of nodular hyperplasia (NH). Immunohistochemistry using monoclonal antibodies to chromogranin and CEA was performed. A scoring system for CCH and semiquantitative evaluation for CEA expression were applied. C-cell hyperplasia was absent in NH cases. In contrast, it was detected in 11% of ATD cases being more frequently observed in Hashimoto's (12.1%) than Graves' disease (6.8%) CCH associated to male sex and older age of Hashimoto's patients. CEA was detected only in ATD cases (33.8%), in C-cells and in follicular cells as well, being more frequently detected in Graves' (44.8%) than Hashimoto's (30.8%) disease. An interesting finding was an emerging possible association of CEA expression with oxyphilic change but not with C-cell hyperplasia in Hashimoto's thyroiditis. No significant correlation was established between CCH and CEA follicular cell expression in neither disease. In conclusion, C-cell hyperplasia and CEA expression may be encountered in the setting of Hashimoto's thyroiditis and Graves' disease.
Hariklia Gakiopoulou; Eleni Litsiou; Konstantinos Valaris; Dimitrios Balafoutas; Efstratios Patsouris; Sofia Tseleni-Balafouta
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-07-03
Journal Detail:
Title:  Endocrine journal     Volume:  57     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-08     Completed Date:  2010-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  693-9     Citation Subset:  IM    
Department of Pathology, School of Medicine, The National & Kapodistrian University of Athens, Athens, Greece.
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MeSH Terms
Aged, 80 and over
Carcinoembryonic Antigen / analysis*
Chromogranins / analysis
Graves Disease / metabolism,  pathology
Hashimoto Disease / metabolism*,  pathology*
Middle Aged
Oxyphil Cells / chemistry*,  pathology
Thyroid Neoplasms / pathology
Thyroid Nodule / pathology
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Chromogranins

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