| Possible adrenocortical insufficiency in postmature neonates. | |
| | |
MedLine Citation:
|
PMID: 1155534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Total plasma cortisol in cord and neonatal blood was measured by a radioassay method in neonates resulting from (1) term vaginal delivery following uncomplicated labor (control group), (2) term vaginal delivery following fetal distress during labor, (3) postterm, postmature vaginal delivery following fetal distress during labor, and (4) postterm, postmature emergency cesarean section performed because of signs of severe fetal distress during labor. Comparison of the mean peripheral plasma cortisol values showed that whereas the mean level (plus or minus S.E.) of the distressed term neonates (22.2 plus or minus 5.3 mug per 100 ml.) use 180 per cent of that of the control group (12.3 plus or minus 1.1 mug per 100 ml.; P smaller than 0.01) the mean level for the vaginally delivered postmature group (7.5 plus or minus 1.8 mug per 100 ml.) was only 61 per cent of that of the control group (P smaller than 0.05). Furthermore, in the postmature group with sufficient intrapartum distress to warrant emergency cesarean section the mean level (4.6 plus or minus 1.5 mug per 100 ml.) was found to be only 37 per cent of that of the control group. No differences were observed among the cord plasma cortisol values. These results are strongly suggestive of a relative adrenocortical insufficiency in postmature neonates. Such insufficiency could result from a defect in any portion of the adrenal-pituitary-hypothalamic axis. Effort is under way to further define such a defect. |
| | |
Authors:
|
U C Nwosu; E E Wallach; T R Boggs; A M Bongiovanni |
Related Documents
:
|
696784 - Fetal heart rate reaction to amniocentesis as an indicator of fetal well-being. 9722124 - Red cell distribution width (rdw) changes in pregnancy. 10535614 - Factor vii deficiency detected in pregnancy: a case report. 10535344 - The influence of prepregnancy body mass index on labor complications. 16614664 - Choice of therapy and mode of delivery in idiopathic intracranial hypertension during p... 2753424 - Chemotherapy in a pregnant rat model. 2.5-fluorouracil: nonlinear kinetics and placenta... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 122 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1975 Aug |
Date Detail:
|
Created Date: 1975-11-08 Completed Date: 1975-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 969-74 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex Diseases
/
etiology* Adrenal Gland Diseases / etiology* Cesarean Section Female Fetal Blood / metabolism Fetal Distress / complications Humans Hydrocortisone / blood Infant, Newborn* Infant, Newborn, Diseases* Infant, Postmature* Placenta Diseases / complications Pregnancy Pregnancy, Prolonged* Syndrome |
| Chemical | |
Reg. No./Substance:
|
50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple births in drug-addicted women.
Next Document: Perinatal factors and neonatal morbidity in twin pregnancy.