Document Detail

Possible links between sickle cell crisis and pentavalent antimony.
MedLine Citation:
PMID:  22665619     Owner:  NLM     Status:  MEDLINE    
For over 60 years, pentavalent antimony (Sb(v)) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb(v) revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb(v), and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb(v) caused the SCC.
Daniel Garcerant; Luisa Rubiano; Victor Blanco; Javier Martinez; Nancy C Baker; Noah Craft
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  86     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-05     Completed Date:  2012-08-20     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-61     Citation Subset:  AIM; IM    
CIDEIM: Centro Internacional De Entrenamiento E Investigaciones Médicas (International Center for Medical Research and Training), Cali, Colombia.
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MeSH Terms
Anemia, Sickle Cell / chemically induced*,  complications
Antimony / adverse effects*
Glutathione / metabolism
Leishmaniasis / complications,  drug therapy
Meglumine / adverse effects*,  therapeutic use
Organometallic Compounds / adverse effects*,  therapeutic use
Grant Support
Reg. No./Substance:
0/Organometallic Compounds; 6284-40-8/Meglumine; 70-18-8/Glutathione; 7440-36-0/Antimony; 75G4TW236W/meglumine antimoniate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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