| Possible links between sickle cell crisis and pentavalent antimony. | |
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MedLine Citation:
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PMID: 22665619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For over 60 years, pentavalent antimony (Sb(v)) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb(v) revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb(v), and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb(v) caused the SCC. |
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Authors:
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Daniel Garcerant; Luisa Rubiano; Victor Blanco; Javier Martinez; Nancy C Baker; Noah Craft |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 86 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-05 Completed Date: 2012-08-20 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 1057-61 Citation Subset: AIM; IM |
Affiliation:
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CIDEIM: Centro Internacional De Entrenamiento E Investigaciones Médicas (International Center for Medical Research and Training), Cali, Colombia. danielgarcerant@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Sickle Cell
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chemically induced*,
complications Antimony / adverse effects* Child Glutathione / metabolism Humans Leishmaniasis / complications, drug therapy Male Meglumine / adverse effects*, therapeutic use Organometallic Compounds / adverse effects*, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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GM066940/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Organometallic Compounds; 6284-40-8/Meglumine; 70-18-8/Glutathione; 7440-36-0/Antimony; 75G4TW236W/meglumine antimoniate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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