| Possible links between intestinal permeablity and food processing: A potential therapeutic niche for glutamine. | |
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MedLine Citation:
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PMID: 20613941 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Increased intestinal permeability is a likely cause of various pathologies, such as allergies and metabolic or even cardiovascular disturbances. Intestinal permeability is found in many severe clinical situations and in common disorders such as irritable bowel syndrome. In these conditions, substances that are normally unable to cross the epithelial barrier gain access to the systemic circulation. To illustrate the potential harmfulness of leaky gut, we present an argument based on examples linked to protein or lipid glycation induced by modern food processing. Increased intestinal permeability should be largely improved by dietary addition of compounds, such as glutamine or curcumin, which both have the mechanistic potential to inhibit the inflammation and oxidative stress linked to tight junction opening. This brief review aims to increase physician awareness of this common, albeit largely unrecognized, pathology, which may be easily prevented or improved by means of simple nutritional changes. |
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Authors:
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Jean Robert Rapin; Nicolas Wiernsperger |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinics (São Paulo, Brazil) Volume: 65 ISSN: 1980-5322 ISO Abbreviation: Clinics (Sao Paulo) Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244734 Medline TA: Clinics (Sao Paulo) Country: Brazil |
Other Details:
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Languages: eng Pagination: 635-43 Citation Subset: IM |
Affiliation:
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University of Burgundy - Dijon, France. jeanrobert.rapin@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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