Document Detail

Possible links between intestinal permeability and food processing: A potential therapeutic niche for glutamine.
MedLine Citation:
PMID:  20613941     Owner:  NLM     Status:  MEDLINE    
Increased intestinal permeability is a likely cause of various pathologies, such as allergies and metabolic or even cardiovascular disturbances. Intestinal permeability is found in many severe clinical situations and in common disorders such as irritable bowel syndrome. In these conditions, substances that are normally unable to cross the epithelial barrier gain access to the systemic circulation. To illustrate the potential harmfulness of leaky gut, we present an argument based on examples linked to protein or lipid glycation induced by modern food processing. Increased intestinal permeability should be largely improved by dietary addition of compounds, such as glutamine or curcumin, which both have the mechanistic potential to inhibit the inflammation and oxidative stress linked to tight junction opening. This brief review aims to increase physician awareness of this common, albeit largely unrecognized, pathology, which may be easily prevented or improved by means of simple nutritional changes.
Jean Robert Rapin; Nicolas Wiernsperger
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  65     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2012-01-16     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  635-43     Citation Subset:  IM    
University of Burgundy - Dijon, France.
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MeSH Terms
Curcumin / therapeutic use
Diet / adverse effects*
Dietary Supplements / adverse effects*
Food Handling*
Food Hypersensitivity / etiology*
Gastrointestinal Motility / physiology*
Glutamine / therapeutic use
Glycosylation End Products, Advanced / adverse effects,  pharmacokinetics
Inflammation / metabolism
Intestinal Absorption / physiology*
Metabolic Syndrome X / etiology
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 458-37-7/Curcumin; 56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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