Document Detail

Possible implication of local immune response in Darier's disease: an immunohistochemical characterization of lesional inflammatory infiltrate.
MedLine Citation:
PMID:  20671948     Owner:  NLM     Status:  MEDLINE    
Cell-mediated immunity is considered to be normal in Darier's Disease (DD), an inherited skin disorder complicated by skin infections. To date, there are no investigations on the local inflammatory infiltrate in DD skin lesions. In this immunohistochemical study we characterized and quantified it, making comparisons with two other inflammatory skin disorders, that is, pemphigus vulgaris (PV) and lichen ruber planus (LRP), and with the normal skin (NSk). We found a significant (P < .05) decrease of CD1a+ Langerhans cells (LCs) in DD, compared to PV, LRP, and NSk, and of CD123+ plasmacytoid dendritic cells (pDCs), compared to PV and LRP. We hypothesize that the genetic damage of keratinocytes might result in a loss of some subsets of dendritic cells and, consequently, in an impaired local immune response, which might worsen the infections that inevitably occur in this disease.
Clelia Miracco; Francesco Pietronudo; Vasileios Mourmouras; Michele Pellegrino; Monica Onorati; Maria Grazia Mastrogiulio; Luca Cantarini; Pietro Luzi
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Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  Mediators of inflammation     Volume:  2010     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-11-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  350304     Citation Subset:  IM    
Section of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte 6, 53100 Siena, Italy.
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MeSH Terms
Antigens, CD1 / immunology
Darier Disease / immunology*,  pathology*
Dendritic Cells / immunology
Interleukin-3 Receptor alpha Subunit / immunology
Langerhans Cells / immunology
Lichen Planus / pathology
Middle Aged
Pemphigus / pathology
Skin / cytology,  immunology*,  pathology*
Reg. No./Substance:
0/Antigens, CD1; 0/CD1a antigen; 0/IL3RA protein, human; 0/Interleukin-3 Receptor alpha Subunit

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