Document Detail


Possible C1q bypass loop activation in the haemolytic uraemic syndrome.
MedLine Citation:
PMID:  371879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrastructural and immunofluorescent microscopic studies were performed on renal tissue obtained from nine patients during the acute and convalescent phase of the haemolytic uraemic syndrome (HUS). All had glomerular deposits of IgM in the absence of circulating immune complexes. This was associated with deposition of C1q during the acute phase, and properdin and C3 during the convalescent phase. C4 was consistently absent. Since such a pattern of complement deposition does not fulfil criteria either for alternate or classical pathway activation, the possibility of C1q bypass loop activation by IgM is suggested.
Authors:
L Nolin; S O'Regan; M Pelletier; G E Rivard; J G Mongeau; P Robitaille
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  35     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-06-11     Completed Date:  1979-06-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Complement Activation*
Complement C1 / analysis
Complement C3 / analysis
Female
Fluorescent Antibody Technique
Hemolytic-Uremic Syndrome / immunology*,  pathology
Humans
Immunoglobulin M / analysis
Infant
Kidney / immunology,  ultrastructure
Male
Microscopy, Electron
Properdin / analysis
Chemical
Reg. No./Substance:
0/Complement C1; 0/Complement C3; 0/Immunoglobulin M; 11016-39-0/Properdin
Comments/Corrections

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