| Possible actions of corticotropin-releasing hormone in regulating porcine corpus luteum function. | |
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MedLine Citation:
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PMID: 20431270 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The objective of the present study was to determine whether corticotropin-releasing hormone (CRH) influences porcine corpus luteum function. The gene expressions of CRH receptors (CRH-R) were determined in the CLs of Chinese Meishan pigs during the estrous cycle. The effects of CRH on progesterone (P), estradiol-17β (E) and prostaglandin (PG) F(2α) secretion by cultured luteal cells were also investigated. Messenger RNAs of the CRH-R were clearly expressed in the CL throughout the estrous cycle, and the mRNA level was higher at the regressed stage than at the other stages (P<0.05). When the cultured luteal cells obtained from the mid-luteal stage CL (days 8-11) were exposed to CRH (50-5000 ng/ml), P secretion by the cells was significantly reduced at the highest dose (P<0.05), whereas CRH had no effect on E and PGF(2α) secretion by the cells. The overall results suggest that CRH inhibits local P production from luteal cells via its specific CRH-R, implying that CRH plays some roles in regulating porcine CL function during the estrous cycle, especially in the period of luteolysis. |
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Authors:
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Ryosuke Sakumoto; Shuichi Ito; Tokushi Komatsu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-23 |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 72 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1173-7 Citation Subset: IM |
Affiliation:
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Reproductive Biology Research Unit, National Institute of Agrobiological Sciences, Ibaraki, Japan. sakumoto@affrc.go.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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