| Possibility of wound dressing using poly(L-leucine)/poly(ethylene glycol)/poly(L-leucine) triblock copolymer. | |
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MedLine Citation:
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PMID: 10632395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ABA-type block copolymers (abbreviated as LEL) composed of poly(L-leucine) (PLL) as the A component and poly(ethylene glycol) (PEG) as the B component were synthesized by ring-opening polymerization of L-leucine N-carboxyanhydride initiated by primary amino group located at both ends of PEG chain. A silver sulfadiazine (AgSD)-impregnated wound dressing of sponge type was prepared by the lyophilization method. Morphological structure of this wound dressing by scanning electron microscopy was observed to be composed of a dense skin layer and a porous inner layer. Equilibrium water content of LEL wound dressing increased with an increase in PEG content in the block copolymer due to the hydrophilicity of PEG. AgSD release from AgSD-impregnated wound dressing in PBS buffer (pH = 7.4) was dependent on PEG content in the block copolymer. Release of AgSD was increased in proportion to the PEG content in the copolymer. Antibacterial capacity of AgSD-impregnated wound dressing was examined in agar plate against Pseudomonas aeruginosa and Staphylococcus aureus. It was found that the suppression of bacterial proliferation in the wound dressing was dependent upon the PEG content. In cytotoxicity test, cell damage did not occur by the release of AgSD from the LEL sponge matrix of AgSD-medicated wound dressing. In in vivo test, granulous tissue formation and wound contraction for the AgSD- and dehydroepiandrosterone-impregnated LEL-2 wound dressing were faster than for any other groups. |
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Authors:
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H J Kim; E Y Choi; J S Oh; H C Lee; S S Park; C S Cho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomaterials Volume: 21 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-09 Completed Date: 2000-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 131-41 Citation Subset: IM |
Affiliation:
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Department of Polymer Engineering, Chonnam National University, Kwangju, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents, Local / administration & dosage, toxicity Bandages* Biocompatible Materials* / chemical synthesis, chemistry, toxicity Humans Leucine* / chemical synthesis, chemistry Male Mice Mice, Inbred BALB C Microbial Sensitivity Tests Peptides* / chemistry, toxicity Polyethylene Glycols* / chemical synthesis, chemistry, toxicity Pseudomonas aeruginosa / drug effects Silver Sulfadiazine / administration & dosage, toxicity Staphylococcus aureus / drug effects Wound Healing* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Biocompatible Materials; 0/Peptides; 0/Polyethylene Glycols; 0/poly(leucine)-poly(ethylene glycol)-poly(leucine) triblock copolymer; 22199-08-2/Silver Sulfadiazine; 25248-98-0/polyleucine; 61-90-5/Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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