Document Detail

Possibility of potential VWD misdiagnosis or misclassification using LIA technology and due to presence of rheumatoid factor.
MedLine Citation:
PMID:  11426494     Owner:  NLM     Status:  MEDLINE    
von Willebrand's disease (VWD) is now recognised to be the most common inherited bleeding disorder and is due to defects and/or deficiencies in von Willebrand factor (VWF). The latex immuno-assay (LIA) procedure has become a popular VWF:Ag detection methodology because of the ability to automate testing. In this report, we present findings which urge caution when normal LIA results are obtained co-incident to striking clinical findings strongly suggestive of VWD, or previous laboratory findings consistent with VWD. As illustrated by a relevant case study, normal LIA results may lead to an "incorrect diagnosis" of "not VWD" or to a potential subtype misdiagnosis, should they be accepted without cross-confirmation using alternative VWF methodologies.
E J Favaloro; M Aboud; C Arthur
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  66     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-06-27     Completed Date:  2001-07-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Department of Haematology, ICPMR, Westmead Hospital, Australia.
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MeSH Terms
Arthritis, Rheumatoid / complications*
Autoimmune Diseases / complications*
Diagnostic Errors
False Negative Reactions
Latex Fixation Tests*
Rheumatoid Factor / blood*
von Willebrand Diseases / blood,  classification,  complications,  diagnosis*
von Willebrand Factor / analysis*
Reg. No./Substance:
0/von Willebrand Factor; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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