| Possibility of postprandial electrogastrography for evaluating vagal/nonvagal cholinergic activity in humans, through simultaneous analysis of postprandial heart rate variability and serum immunoreactive hormone levels. | |
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MedLine Citation:
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PMID: 7717319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate changes in postprandial electrogastrography (EGG) from the neurohormonal mechanisms. METHODS: We measured EGG indices [frequency amplitude of normal 3-cpm (EGG-3 cpm)], high frequency amplitude of heart rate variability which has reflected cardiac parasympathetic tone, and several serum immunoreactive (ir)-hormone levels in 12 fasted male volunteers (mean age 25.3 yr). RESULTS: Immediately after the liquid food intake (250 kcal), a transient decrease in EGG-3 cpm frequency (from 0.045 +/- 0.001 Hz to 0.040 +/- 0.001 Hz; p < 0.05) accompanied by an increase in high frequency amplitude (from 31.05 +/- 3.45 ms to 39.10 +/- 4.08 ms; p < 0.05), and a serum immunoreactive gastrin level increase (from 38.72 +/- 4.92 pmol/L to 54.00 +/- 10.45 pmol/L; p < 0.05) and an immunoreactive somatostatin level decrease (from 15.00 +/- 0.43 pmol/L to 13.70 +/- 0.46 pmol/L; p < 0.01) were observed, suggesting vagal excitement. EGG-3 cpm amplitude and serum immunoreactive human pancreatic polypeptide (hPP) levels significantly increased soon after ingestion, and these changes lasted for 30 min. Furthermore, there was a positive correlation between changes in EGG-3 cpm amplitude and those in serum immunoreactive hPP levels during the postprandial periods (r = 0.55, p < 0.001). CONCLUSIONS: Considering the reports that a cholinergic, nonvagal pathway is of major importance in food-stimulated hPP release, the present results suggest that postprandial changes in EGG-3 cpm frequency and amplitude might be a good tool for evaluating not only vagal but also nonvagal cholinergic activity in the human gut. |
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Authors:
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H Kaneko; M Sakakibara; T Mitsuma; K Morise |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 90 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-05-15 Completed Date: 1995-05-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 603-9 Citation Subset: IM |
Affiliation:
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Fourth Department of Internal Medicine, Aichi Medical University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autonomic Pathways / physiology* Eating / physiology* Electrophysiology Gastrins / blood Heart Rate / physiology* Humans Male Neuropeptides / blood* Pancreatic Polypeptide / blood Receptors, Cholinergic / physiology* Somatostatin / blood Stomach / physiology* Vagus Nerve / physiology |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Neuropeptides; 0/Receptors, Cholinergic; 51110-01-1/Somatostatin; 59763-91-6/Pancreatic Polypeptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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