| Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner. | |
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MedLine Citation:
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PMID: 22042538 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECT: To investigate the potential of a clinical 3 T scanner to perform MRI of small rodents. MATERIALS AND METHODS: Different dedicated small animal coils and several imaging sequences were evaluated to optimize image quality with respect to SNR, contrast and spatial resolution. As an application, optimal grey-white-matter contrast and resolution were investigated for rats. Furthermore, manganese-enhanced MRI was applied in mice with unilateral crush injury of the optic nerve to investigate coil performance on topographic mapping of the visual projection. RESULTS: Differences in SNR and CNR up to factor 3 and more were observed between the investigated coils. The best grey-white matter contrast was achieved with a high resolution 3D T (2)-weighted TSE (SPACE) sequence. Delineation of the retino-tectal projection and detection of defined visual pathway damage on the level of the optic nerve could be achieved by using a T (1)-weighted, 3D gradient echo sequence with isotropic resolution of (0.2 mm)(3). CONCLUSIONS: Experimental studies in small rodents requiring high spatial resolution can be performed by using a clinical 3 T scanner with appropriate dedicated coils. |
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Authors:
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Karl-Heinz Herrmann; Silvio Schmidt; Alexandra Kretz; Ronny Haenold; Ines Krumbein; Martin Metzler; Christian Gaser; Otto W Witte; Jürgen R Reichenbach |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-22 |
Journal Detail:
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Title: Magma (New York, N.Y.) Volume: - ISSN: 0968-5243 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310752 Medline TA: MAGMA Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medical Physics Group, Institute for Diagnostic and Interventional Radiology I, Jena University Hospital, Philosophenweg 3, Gebäude 5, 07743, Jena, Germany, karl-heinz.herrmann@med.uni-jena.de. |
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