Document Detail


Positron imaging feasibility studies. II: Characteristics of 2-deoxyglucose uptake in rodent and canine neoplasms: concise communication.
MedLine Citation:
PMID:  6974768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uptake of [3H]2-deoxyglucose was studied in BALB/c mice with EMT-6 sarcoma, in Buffalo rats with Morris 7777 hepatoma, and in eight dogs with spontaneous neoplasms: five osteosarcomas and three diffuse lymphomas. High tumor-to-tissue ratios were observed for all tumor types studied. In rodents, peak levels of uptake occurred between 30 min and 1 hr, with a slow loss from the tumor of about 10% per hour thereafter. In dogs there was considerable variability in uptake, both between individuals and at different tumor sites within an individual. Necrotic tumor did not take up the radiotracer. Absolute uptakes, when normalized for body weight, were similar for spontaneous and transplanted neoplasms. These studies provide additional support for the concept that positron emission tomography can be used to obtain functional images of important metabolic processes of tumors, including glycolysis.
Authors:
S M Larson; P L Weiden; Z Grunbaum; H G Kaplan; J S Rasey; M M Graham; G E Sale; G D Harp; D L Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  22     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  875-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Deoxy Sugars / metabolism*
Deoxyglucose / diagnostic use,  metabolism*
Dog Diseases / metabolism
Dogs
Liver Neoplasms, Experimental / metabolism*
Mice
Mice, Inbred BALB C
Neoplasms / metabolism*,  radionuclide imaging,  veterinary
Rats
Rats, Inbred BUF
Sarcoma, Experimental / metabolism*
Tomography, Emission-Computed*
Grant Support
ID/Acronym/Agency:
CA18105/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Deoxy Sugars; 154-17-6/Deoxyglucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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