| Positron emission tomography with F-18-fluorodeoxyglucose in a combined staging strategy of esophageal cancer prevents unnecessary surgical explorations. | |
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MedLine Citation:
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PMID: 15623445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Distant metastases or local invasion are frequently found during the explorative phase of surgery for esophageal cancer. This study was performed to determine the rate of patients with incurable disease encountered during exploration and to examine the impact of preoperative staging, including positron emission tomography (PET), on the number of unnecessary explorations. The records of 203 patients with esophageal cancer who were eligible for curative resection were retrospectively reviewed. The surgical reports were analyzed to obtain the reasons for abandoning resection. Furthermore, the different staging modalities according to the related time interval were reviewed for each patient to analyze the influence of them on the number of explorations. After exploratory surgery, resection was abandoned in 78 of the 203 patients (38%) because of distant metastases (n=59; 29%), metastatic spread and local irresectability (n=5; 2%), and local irresectability (n=14; 7%). In a logistic regression model with all preoperative staging modalities and the year of examination as independent variables, F-18-fluorodeoxyglucose (FDG)-PET) was the only modality that predicts intended curative resection in these patients (P<0.001). In patients with esophageal cancer who are suitable for potentially curative surgery, resection was abandoned mainly because of distant metastases encountered during exploration. The addition of FDG-PET may have reduced the rate of unnecessary surgery in this group of patients. |
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Authors:
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Henderik L van Westreenen; Pierre A M Heeren; Hendrik M van Dullemen; Eric J van der Jagt; Pieter L Jager; Henk Groen; John Th M Plukker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Volume: 9 ISSN: 1091-255X ISO Abbreviation: J. Gastrointest. Surg. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-29 Completed Date: 2005-06-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706084 Medline TA: J Gastrointest Surg Country: United States |
Other Details:
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Languages: eng Pagination: 54-61 Citation Subset: IM |
Affiliation:
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Department of Surgical Oncology, University Hospital Groningen, Groningen, the Netherlands. h.l.westreenen@chir.azg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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radionuclide imaging*,
secondary,
surgery* Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / surgery Endosonography Esophageal Neoplasms / radionuclide imaging*, secondary, surgery* Esophagectomy / methods* Female Fluorodeoxyglucose F18 / diagnostic use Humans Male Middle Aged Neoplasm Staging Positron-Emission Tomography Radiopharmaceuticals / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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