| Positron emission tomography with CT in the evaluation of non-small cell lung cancer in populations with a high prevalence of tuberculosis. | |
| | |
MedLine Citation:
|
PMID: 16423207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE AND BACKGROUND: To determine the utility of positron emission tomography with CT (PET-CT) in the evaluation of non-small cell lung cancer (NSCLC) in an Asian context where tuberculosis rates are moderately high. METHODS: Case records of consecutive patients with NSCLC undergoing PET-CT at the Singapore General Hospital over a 1-year period were retrospectively reviewed. The authors evaluated the sensitivity and specificity of PET-CT at their institution using surgical pathology or the tincture of time as the gold standard. RESULTS: A total of 54 patients underwent PET-CT during this period. Seven patients were evaluated for solitary pulmonary nodule, for which PET-CT gave a sensitivity of 100% and specificity of 75%. There was one patient with false positive PET-CT due to active tuberculosis. In total, 41 patients underwent PET-CT for staging of NSCLC. There was one false positive (patient was found to have active tuberculous lymphadenitis) and one false negative for NSCLC. This gave a sensitivity of 92.3% and a specificity of 95%. Histology from the adrenal glands was available in two patients with PET-CT that was positive for adrenal metastases. One proved to be benign whereas the other was consistent with metastasis. Two patients had PET-CT positive for liver metastases, which was verified by histology. Two patients with positive PET-CT for lesions in the colon turned out to be benign histologically. CONCLUSIONS: Positron emission tomography with CT for the evaluation and follow-up of solitary pulmonary nodule and NSCLC can provide additional useful information to conventional radiology for treatment planning and a non-invasive determination of prognosis. However, physicians need to be aware of the limitations of this imaging modality, particularly when tuberculosis has a high prevalence in the population. |
| | |
Authors:
|
Su-Ying Low; Philip Eng; Gilbert H W Keng; David C E Ng |
Related Documents
:
|
15514377 - Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-d-glucose positron em... 19917927 - Neck response to chemoradiotherapy: complete radiographic response correlates with path... 15561807 - The role of pet scan in diagnosis, staging, and management of non-small cell lung cancer. 9800237 - Applications of pet in lung cancer. 8892197 - Magnetic resonance imaging of neurogenic tumors of the thoracic inlet: determination of... 11390547 - Ictal hyperperfusion of cerebellum and basal ganglia in temporal lobe epilepsy: spect s... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Respirology (Carlton, Vic.) Volume: 11 ISSN: 1323-7799 ISO Abbreviation: Respirology Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2006-01-20 Completed Date: 2006-06-20 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
|
Languages: eng Pagination: 84-9 Citation Subset: IM |
Affiliation:
|
Department of Respiratory and Critical Care Medicine, Singapore General Hospital. gm31sy@sgh.com.sg |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carcinoma, Non-Small-Cell Lung
/
pathology,
radiography*,
radionuclide imaging* Female Humans Lung Neoplasms / pathology, radiography*, radionuclide imaging* Male Middle Aged Neoplasm Staging Positron-Emission Tomography* Retrospective Studies Sensitivity and Specificity Singapore Solitary Pulmonary Nodule / pathology, radiography*, radionuclide imaging* Tomography, X-Ray Computed* Tuberculosis / complications*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simkania negevensis and newly diagnosed asthma: a case-control study in 1- to 6-year-old children.
Next Document: Intrapleural cisplatin and OK432 therapy for malignant pleural effusion caused by non-small cell lun...