| Positron emission tomography/computed tomography and whole-body magnetic resonance imaging in staging of advanced nonsmall cell lung cancer--initial results. | |
| | |
MedLine Citation:
|
PMID: 18424949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate and compare positron emission tomography/computed tomography (PET/CT) with whole-body magnetic resonance imaging (wbMRI) in the correct staging of patients with advanced nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: Fifty-two patients with an NSCLC stage IIIa or IIIb (36 males and 16 females) were included in this study. Patients were referred to our department for restaging. Within 1 week PET/CT and wbMRI were performed in all patients. Images were examined independently by 2 experienced physicians from the Department of Nuclear Medicine and Radiology. Afterward, consensus reading was performed. In 22 patients, surgery served as gold standard, whereas in 30 patients, follow-up controls (after 2 months) were performed. RESULTS: The use of wbMRI correctly T-staged all patients. Especially volume interpolated breathhold examination sequence correctly T-staged all tumors. PET/CT did not correctly stage chest wall infiltration in 4 cases [sensitivity 92.3% (P < 0.05 to wbMRI)/specificity 100%], verified by surgery. PET/CT correctly N-staged 51 patients (sensitivity 96.1%/specificity 100%). WbMRI showed a significant tendency to understage N-status [sensitivity 88.5% (P < 0.05)/specificity 96.1%]. Different N-status by PET/CT changed operability in 4 patients. In 2 patients, distant metastases were detected by both techniques. CONCLUSION: In the correct staging of advanced NSCLC, PET/CT has advantages in N-staging. This is of high relevance for therapy planning. WbMRI especially using volume interpolated breathhold examination sequences, has certain advantages in T-staging. |
| | |
Authors:
|
Christian Plathow; Philip Aschoff; Mathias Philip Lichy; Susanne Eschmann; Thomas Hehr; Ingo Brink; Claus D Claussen; Christina Pfannenberg; Heinz-Peter Schlemmer |
Related Documents
:
|
10823629 - Value of (18f)-fdg positron emission tomography, computed tomography, and magnetic reso... 9885779 - Imaging of abdominal manifestations of melanoma. 19022059 - Chapter 7. molecular imaging of tumor vasculature. 10999049 - The role of radiation in the management of hodgkin's disease: an update. 21076089 - Breast cancer: comparative effectiveness of positron emission mammography and mr imagin... 18183409 - A case of pathologic fracture of femur whose primary tumor and occult metastases were a... 10823629 - Value of (18f)-fdg positron emission tomography, computed tomography, and magnetic reso... 8588679 - Petrous apex arachnoid cyst: radiographic confusion with primary cholesteatoma. 9276049 - Arthroscopic microdiscectomy: comparison of preoperative and postoperative imaging stud... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
|
Title: Investigative radiology Volume: 43 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-04-21 Completed Date: 2008-09-19 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 290-7 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Tuebingen, Tuebingen, Germany. christian.plathow@uniklinik-freiburg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Carcinoma, Non-Small-Cell Lung / diagnosis*, surgery Contrast Media / administration & dosage Female Fluorodeoxyglucose F18 / diagnostic use Follow-Up Studies Humans Image Enhancement / methods Iohexol / analogs & derivatives, diagnostic use Lung / pathology*, radiography, radionuclide imaging Magnetic Resonance Imaging / methods* Male Middle Aged Neoplasm Staging Observer Variation Positron-Emission Tomography / methods* Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* Whole Body Imaging / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 63503-12-8/Fluorodeoxyglucose F18; 66108-95-0/Iohexol; 73334-07-3/iopromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left ventricular and left atrial dimensions and volumes: comparison between dual-source CT and echoc...
Next Document: Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature.