| Positron emission tomography for preoperative staging of colorectal carcinoma. | |
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MedLine Citation:
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PMID: 8306836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Positron emission tomography (PET) is an imaging technique based on in vivo cellular metabolism. Increased glucose metabolism in neoplastic cells is detected by using fluorine-18 deoxyglucose. In an ongoing pilot study to determine the usefulness of this technique, PET is compared with computerized tomography (CT) for the preoperative staging of colorectal carcinoma. METHODS: Sixteen patients were evaluated with both PET and CT of the abdomen and pelvis. Results were compared with operative and histopathologic findings. Fifteen malignant lesions were found in 16 patients by histology. PET had a positive predictive value of 93 percent and a negative predictive value of 50 percent. By comparison CT had a positive predictive value of 100 percent and a negative predictive value of 27 percent. CONCLUSIONS: These preliminary results indicate that PET has increased sensitivity for staging colorectal carcinoma, whereas CT has higher specificity. The predictive value of a positive PET compares favorably with CT. Furthermore, the predictive accuracy for detection of colorectal carcinoma is 83 percent for PET and 56 percent for CT. |
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Authors:
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P M Falk; N C Gupta; A G Thorson; M P Frick; B M Boman; M A Christensen; G J Blatchford |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 37 ISSN: 0012-3706 ISO Abbreviation: Dis. Colon Rectum Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-03-15 Completed Date: 1994-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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Section of Colon and Rectal Surgery, Creighton University School of Medicine, Omaha, Nebraska 68131. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Colonic Neoplasms / pathology, radiography, radionuclide imaging* Deoxyglucose / diagnostic use Female Fluorine Radioisotopes / diagnostic use Humans Male Middle Aged Neoplasm Staging Pilot Projects Predictive Value of Tests Prospective Studies Rectal Neoplasms / pathology, radiography, radionuclide imaging* Sensitivity and Specificity Tomography, Emission-Computed* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 154-17-6/Deoxyglucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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