| Positron-emission tomography in tardive dyskinesia. | |
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MedLine Citation:
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PMID: 8555748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral glucose metabolic rates were determined in normal control subjects (n = 26) and schizophrenic patients with tardive dyskinesia (n = 14). Globus pallidus and primary motor cortex (precentral gyrus) metabolic values divided by those of the cerebral hemispheres were significantly increased in the patient group. A similar metabolic pattern has not been reported for schizophrenic patients without tardive dyskinesia, and the abnormalities were demonstrated despite the normal appearance of the basal ganglia on X-ray CT. The findings differed markedly from the reduced metabolic rates of the basal ganglia previously identified in other choreiform disorders, including Huntington's and Wilson's diseases. The findings suggest that tardive dyskinesia is characterized by increased pallidal synaptic activity resulting from either altered striatopallidal input or increased pallidal interneuron firing. |
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Authors:
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J J Pahl; J C Mazziotta; G Bartzokis; J Cummings; L Altschuler; J Mintz; S R Marder; M E Phelps |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of neuropsychiatry and clinical neurosciences Volume: 7 ISSN: 0895-0172 ISO Abbreviation: J Neuropsychiatry Clin Neurosci Publication Date: 1995 |
Date Detail:
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Created Date: 1996-02-27 Completed Date: 1996-02-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8911344 Medline TA: J Neuropsychiatry Clin Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 457-65 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Oklahoma Health Science Center, Oklahoma City, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antipsychotic Agents / adverse effects*, therapeutic use Blood Glucose / metabolism* Brain / drug effects*, radionuclide imaging Brain Mapping Dominance, Cerebral / drug effects, physiology Dyskinesia, Drug-Induced / radionuclide imaging* Female Globus Pallidus / drug effects, radionuclide imaging Humans Male Middle Aged Schizophrenia / drug therapy*, radionuclide imaging Synaptic Transmission / drug effects, physiology Tomography, Emission-Computed* |
| Grant Support | |
ID/Acronym/Agency:
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P01 NS15654/NS/NINDS NIH HHS; R01 MH3791-AC03-76-SF0012/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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