Document Detail

Positron-emission tomography in tardive dyskinesia.
MedLine Citation:
PMID:  8555748     Owner:  NLM     Status:  MEDLINE    
Cerebral glucose metabolic rates were determined in normal control subjects (n = 26) and schizophrenic patients with tardive dyskinesia (n = 14). Globus pallidus and primary motor cortex (precentral gyrus) metabolic values divided by those of the cerebral hemispheres were significantly increased in the patient group. A similar metabolic pattern has not been reported for schizophrenic patients without tardive dyskinesia, and the abnormalities were demonstrated despite the normal appearance of the basal ganglia on X-ray CT. The findings differed markedly from the reduced metabolic rates of the basal ganglia previously identified in other choreiform disorders, including Huntington's and Wilson's diseases. The findings suggest that tardive dyskinesia is characterized by increased pallidal synaptic activity resulting from either altered striatopallidal input or increased pallidal interneuron firing.
J J Pahl; J C Mazziotta; G Bartzokis; J Cummings; L Altschuler; J Mintz; S R Marder; M E Phelps
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  7     ISSN:  0895-0172     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-27     Completed Date:  1996-02-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  457-65     Citation Subset:  IM    
Department of Psychiatry, University of Oklahoma Health Science Center, Oklahoma City, USA.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Blood Glucose / metabolism*
Brain / drug effects*,  radionuclide imaging
Brain Mapping
Dominance, Cerebral / drug effects,  physiology
Dyskinesia, Drug-Induced / radionuclide imaging*
Globus Pallidus / drug effects,  radionuclide imaging
Middle Aged
Schizophrenia / drug therapy*,  radionuclide imaging
Synaptic Transmission / drug effects,  physiology
Tomography, Emission-Computed*
Grant Support
P01 NS15654/NS/NINDS NIH HHS; R01 MH3791-AC03-76-SF0012/MH/NIMH NIH HHS
Reg. No./Substance:
0/Antipsychotic Agents; 0/Blood Glucose

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