| Positron emission tomography in surveillance of head and neck squamous cell carcinoma after definitive chemoradiotherapy. | |
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MedLine Citation:
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PMID: 19177422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We assessed the role of (18)F-fluoro-deoxy-glucose positron emission tomography (PET) in detecting head and neck squamous cell carcinoma (HNSCC) after definitive chemoradiotherapy (CRT). METHODS: A prospective study presented 80 PET before and after CRT for 44 patients, including 44 first-time post-CRT scans performed between 12 and 17 weeks after radiotherapy completion, as well as 10 repeated scans in the subsequent follow-up. PET interpretations were compared with clinicopathologic outcomes. RESULTS: PET demonstrated better performance than CT in post-CRT surveillance. Considering all 54 post-CRT PET scans, sensitivity for detecting primary tumors was 100%, specificity 93%, positive predictive value (PPV) 80%, and negative predictive value (NPV) 100%. For cervical diseases, sensitivity was 100%, specificity 98%, PPV 92%, and NPV 100%. For distant metastases, sensitivity was 100%, specificity 98%, PPV 86%, and NPV 100%. CONCLUSIONS: Negative PET readings were reliable for predicting free of HNSCC and helpful for selected patients in post-CRT surveillance. |
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Authors:
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Yi-Fen Wang; Ren-Shyan Liu; Pen-Yuan Chu; Feng-Chi Chang; Shyh-Kuan Tai; Tung-Lung Tsai; Jui-Lin Huang; Shyue-Yih Chang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Head & neck Volume: 31 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-19 Completed Date: 2009-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 442-51 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan. yfwangent@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Squamous Cell / radiography, radionuclide imaging*, therapy Combined Modality Therapy Female Fluorodeoxyglucose F18 / diagnostic use Head and Neck Neoplasms / radiography, radionuclide imaging*, therapy Humans Lymphatic Metastasis Male Middle Aged Neck Positron-Emission Tomography* Predictive Value of Tests Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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