| Positron emission tomography/computed tomography in the management of recurrent/metastatic breast cancer: a large retrospective study from the Royal Marsden Hospital. | |
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MedLine Citation:
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PMID: 20624786 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Despite the increasing use of positron emission tomography/computed tomography (PET/CT) in the management of patients with breast cancer, its role is yet to be defined. PATIENTS AND METHODS: We reviewed PET/CT scans carried out in breast cancer patients, the indication, concordance/discordance with other imaging and whether their use had altered patient management. RESULTS: PET/CT scans (233) were carried out in 122 patients between July 2004 and October 2008. Indications were as follows: staging (S) (91), response assessment (RA) (87), clarification (C) of findings on other imaging (32) and reassurance (ASS) (23). In the S group, positive scans were helpful in accurately defining the extent of disease and guided localised or systemic treatment. PET/CT was particularly useful for detecting lytic bone metastases. One-third of the scans was carried out for RA. PET/CT allowed early RA and in some cases appropriate discontinuation of ineffective treatment. PET/CT was used effectively for the clarification of indeterminate lesions on CT (18), magnetic resonance imaging (15) and bone scan (13). In the ASS group, all scans were negative. CONCLUSIONS: PET/CT is useful in accurately staging metastatic disease, assessing response to systemic treatment and clarifying equivocation on other imaging. Incorporation of PET/CT in these areas contributes to breast cancer management optimisation. |
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Authors:
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A Constantinidou; A Martin; B Sharma; S R D Johnston |
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Publication Detail:
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Type: Journal Article Date: 2010-07-12 |
Journal Detail:
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Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 22 ISSN: 1569-8041 ISO Abbreviation: Ann. Oncol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: England |
Other Details:
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Languages: eng Pagination: 307-14 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Breast Unit. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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